Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Stem Cell Reports
; 17(4): 711-714, 2022 04 12.
Article
in English
| MEDLINE | ID: covidwho-1756288
ABSTRACT
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in "universal" human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pluripotent Stem Cells
/
Pandemics
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Stem Cell Reports
Year:
2022
Document Type:
Article
Affiliation country:
J.stemcr.2022.02.014
Similar
MEDLINE
...
LILACS
LIS