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Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variant.
Boscolo-Rizzo, Paolo; Tirelli, Giancarlo; Meloni, Pierluigi; Hopkins, Claire; Madeddu, Giordano; De Vito, Andrea; Gardenal, Nicoletta; Valentinotti, Romina; Tofanelli, Margherita; Borsetto, Daniele; Lechien, Jerome R; Polesel, Jerry; De Riu, Giacomo; Vaira, Luigi Angelo.
  • Boscolo-Rizzo P; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Tirelli G; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Meloni P; Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Hopkins C; Guy's and St Thomas' Hospitals, London, UK.
  • Madeddu G; Department of Medical, Surgical and Experimental Sciences, Infectious Disease Unit, University of Sassari, Sassari, Italy.
  • De Vito A; Department of Medical, Surgical and Experimental Sciences, Infectious Disease Unit, University of Sassari, Sassari, Italy.
  • Gardenal N; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Valentinotti R; Department of Prevention, Section of Hygiene and Public Health, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Trieste, Italy.
  • Tofanelli M; Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
  • Borsetto D; Department of ENT, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, UK.
  • Lechien JR; Department of Otolaryngology-Head Neck Surgery, Elsan Hospital, Paris, France.
  • Polesel J; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aviano, Italy.
  • De Riu G; Department of Medical, Surgical and Experimental Sciences, Maxillofacial Surgery Operative Unit, University of Sassari, Sassari, Italy.
  • Vaira LA; Department of Medical, Surgical and Experimental Sciences, Maxillofacial Surgery Operative Unit, University of Sassari, Sassari, Italy.
Int Forum Allergy Rhinol ; 2022 Mar 14.
Article in English | MEDLINE | ID: covidwho-1756550
ABSTRACT

BACKGROUND:

The aim of this study was to estimate the prevalence of self-reported chemosensory dysfunction in a study cohort of subjects who developed a mild-to-moderate coronavirus disease 2019 (COVID-19) in the period from January 17, 2022, to February 4, 2022 (Omicron proxy period) and compared that with a historical series of patients testing positive for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection between March and April, 2020 (comparator period).

METHODS:

Prospective study based on the 22-item Sino-Nasal Outcome Tool (SNOT-22), item "sense of smell or taste" and additional outcomes.

RESULTS:

Patients' characteristics and clinical presentations of COVID-19 were evaluated and compared in 779 patients, 338 of the study cohort and 441 of the historical series. The prevalence of self-reported chemosensory dysfunction during the proxy Omicron period (32.5%; 95% confidence interval [CI], 27.6-37.8) was significantly lower from that during the comparator period (66.9%; 95% CI, 62.3-71.3) (p < 0.001). Nearly one-quarter of patients (24.6%; 95% CI, 20.1-29.5) reported an altered sense of smell during the proxy Omicron period compared to 62.6% (95% CI, 57.9-67.1) during the comparator period (p < 0.001). Similarly, the prevalence of an altered sense of taste dropped to 26.9% (95% CI, 22.3-32.0) during the proxy Omicron period from 57.4% (95% CI, 52.6-62.0) during the comparator period (p < 0.001). The severity of chemosensory dysfunction was lower in the proxy Omicron period compared to the comparator period (p < 0.001).

CONCLUSION:

The prevalence and the severity of COVID-19-associated smell and taste dysfunction has dropped significantly with the advent of the Omicron variant but it still remains above 30%.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Risk factors Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Alr.22995

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Risk factors Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Alr.22995