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COVID-19-associated Cryptococcus infection (CACI): a review of literature and clinical pearls.
Regalla, Dinesh; VanNatta, Mollie; Alam, Mohammad; Malek, Alexandre E.
  • Regalla D; Division of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
  • VanNatta M; Department of Pharmacy, Ochsner LSU Health Shreveport, Shreveport, LA, USA.
  • Alam M; Division of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
  • Malek AE; Division of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Alex.e.malek@gmail.com.
Infection ; 50(4): 1007-1012, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1756953
ABSTRACT

BACKGROUND:

Cryptococcal infection has been increasingly reported in patients with COVID-19 infection, but the epidemiological factors, presentation, diagnostic certainty, and outcome have not been well-described.

METHODS:

We reviewed the published cases of COVID-19-associated Cryptococcus infections (CACI) to shed the light on the burden of this infection.

RESULTS:

We identified 13 patients with confirmed cryptococcal infection. Cryptococcus infection was primarily seen in patients with severe COVID-19 disease who received corticosteroids therapy and admitted to the intensive care unit. Pulmonary CACI was the most common reported infection followed by cryptococcal meningitis.

CONCLUSION:

In light of the high mortality rate, clinicians should maintain a high clinical suspicion of CACI in critically ill patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Meningitis, Cryptococcal / Cryptococcosis / Cryptococcus / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Infection Year: 2022 Document Type: Article Affiliation country: S15010-022-01805-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Meningitis, Cryptococcal / Cryptococcosis / Cryptococcus / COVID-19 Type of study: Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Infection Year: 2022 Document Type: Article Affiliation country: S15010-022-01805-y