Does maternal SARS-CoV-2 infection or SARS-CoV-2 vaccination trigger an inflammatory response in the fetus?
American Journal of Obstetrics and Gynecology
; 226(1):S28-S29, 2022.
Article
in English
| EMBASE | ID: covidwho-1757066
ABSTRACT
Objective:
SARS-CoV-2 infection triggers a significant maternal inflammatory response. There is a dearth of data regarding whether maternal SARS-CoV-2 infection or SARS-CoV-2 vaccination triggers an inflammatory response in the fetus. Fetal Inflammatory Response Syndrome (FIRS) has been described in other clinical conditions such as intraamniotic infection and has been defined as a cord blood Interleukin-6 (IL-6) level > 11 pg/ml. The objective of the study is to evaluate Il-6 levels in the cord blood of three delivering women SARS-CoV-2 infection group, SARS-CoV-2 vaccinated group, and a control group. StudyDesign:
A prospective case control study of a total of 61 pregnant women who presented for delivery at William Beaumont Hospital, Royal Oak, MI. All patients were tested for SARS-CoV-2 infection by polymerase chain reaction test (PCR). Three groups were evaluated 22 pregnant women with positive SARS-CoV-2 PCR test (case group), 23 Pregnant women with negative SARS-CoV-2 PCR test (control group), and 16 pregnant women who had recent SAR-CoV-2 vaccination and a negative SARS-CoV-2 PCR test. At delivery, cord blood was collected for IL-6 levels.Results:
IL-6 level (mean +/- SEM) was for the case group 8.99 +/- 3.33 pg/ml, control group 5.19 +/- 0.76 pg/ml, and vaccine group 7.11 +/- 2.47 pg/ml. There was no statistical difference between the three groups with ANOVA p-value 0.51. Pairwise comparison also revealed no statistical difference with p-values for case versus control, case versus vaccine, and control versus vaccine being 0.52, 0.85, and 0.84 respectively.Conclusion:
IL-6, the most sensitive measure of inflammation in obstetric practice, did not identify increased inflammation in PCR negative newborns of vaccinated or SARS-CoV-2 infected mothers. Evaluation using other markers of possible intrauterine inflammation is warranted.
endogenous compound; interleukin 6; vaccine; adult; analysis of variance; case control study; conference abstract; controlled study; coronavirus disease 2019; female; fetus; gene amplification; gene expression; human; inflammation; major clinical study; mother; newborn; nonhuman; obstetric delivery; polymerase chain reaction; pregnant woman; prospective study; Severe acute respiratory syndrome coronavirus 2; umbilical cord blood; vaccination
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Topics:
Vaccines
Language:
English
Journal:
American Journal of Obstetrics and Gynecology
Year:
2022
Document Type:
Article
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