The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury.
JACC Basic Transl Sci
; 7(3): 294-308, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1757448
ABSTRACT
The mechanisms of coronavirus disease-2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
CMR, cardiovascular magnetic resonance; COVID-19; COVID-19, coronavirus disease-2019; CT, Computerized Tomography; LGE, late gadolinium enhancement; MI, myocardial infarction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; athlete; cardiovascular magnetic resonance imaging; inflammation; myocardial injury; myocarditis; sudden cardiac death; troponin
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
/
Vaccines
Language:
English
Journal:
JACC Basic Transl Sci
Year:
2022
Document Type:
Article
Affiliation country:
J.jacbts.2021.10.011
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