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Microalgal drugs: A promising therapeutic reserve for the future.
Ahirwar, Ankesh; Kesharwani, Khushboo; Deka, Rahul; Muthukumar, Shreya; Khan, Mohd Jahir; Rai, Anshuman; Vinayak, Vandana; Varjani, Sunita; Joshi, Khashti Ballabh; Morjaria, Shruti.
  • Ahirwar A; Diatom Nanoengineering and Metabolism Laboratory (DNM), School of Applied Science, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
  • Kesharwani K; Department of Chemistry, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
  • Deka R; Diatom Nanoengineering and Metabolism Laboratory (DNM), School of Applied Science, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
  • Muthukumar S; Diatom Nanoengineering and Metabolism Laboratory (DNM), School of Applied Science, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
  • Khan MJ; Diatom Nanoengineering and Metabolism Laboratory (DNM), School of Applied Science, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
  • Rai A; MMU, Deemed University, School of Engineering, Department of Biotechnology, Ambala, Haryana, 133203, India.
  • Vinayak V; Diatom Nanoengineering and Metabolism Laboratory (DNM), School of Applied Science, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India. Electronic address: kapilvinayak@gmail.com.
  • Varjani S; Gujarat Pollution Control Board, Gandhinagar, Gujarat 382 010, India. Electronic address: drsvs18@gmail.com.
  • Joshi KB; Department of Chemistry, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
  • Morjaria S; Diatom Nanoengineering and Metabolism Laboratory (DNM), School of Applied Science, Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh 470003, India.
J Biotechnol ; 349: 32-46, 2022 Apr 10.
Article in English | MEDLINE | ID: covidwho-1757477
ABSTRACT
Over the decades, a variety of chemically synthesized drugs are being used to cure existing diseases but often these drugs could not be effectively employed for the treatment of serious and newly emerging diseases. Fortunately, in nature there occurs immense treasure of plants and microorganisms which are living jewels with respect to their richness of medically important metabolites of high value. Hence, amongst the existing microorganism(s), the marine world offers a plethora of biological entities that can contribute to alleviate numerous human ailments. Algae are one such photosynthetic microorganism found in both marine as well as fresh water which are rich source of metabolites known for their nutrient content and health benefits. Various algal species like Haematococcus, Diatoms, Griffithsia, Chlorella, Spirulina, Ulva, etc. have been identified and isolated to produce biologically active and pharmaceutically important high value compounds like astaxanthin, fucoxanthin, sulphur polysaccharides mainly galactose, rhamnose, xylose, fucose etc., which show antimicrobial, antifungal, anti-cancer, and antiviral activities. However, the production of either of these bio compounds is favored under conditions of stress. This review gives detailed information on various nutraceutical metabolites extracted from algae. Additionally focus has been made on the role of these bio compounds extracted from algae especially sulphur polysaccharides to treat several diseases with prospective treatment for SARS-CoV-2. Lastly it covers the knowledge gaps and future perspectives in this area of research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chlorella / Microalgae / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: J Biotechnol Journal subject: Biotechnology Year: 2022 Document Type: Article Affiliation country: J.jbiotec.2022.03.012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chlorella / Microalgae / COVID-19 Drug Treatment Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: J Biotechnol Journal subject: Biotechnology Year: 2022 Document Type: Article Affiliation country: J.jbiotec.2022.03.012