Myocarditis After COVID-19 Vaccination: A Systematic Review of Case Studies
JACC: Cardiovascular Interventions
; 15(4):S30, 2022.
Article
in English
| EMBASE | ID: covidwho-1757492
ABSTRACT
Background:
The coronavirus disease of 2019 (COVID-19) is a global pandemic with over 200 million cases and four million deaths worldwide. Anti-COVID-19 vaccinations have had exceptional success in subduing the incidence, prevalence, and disease severity of COVID-19, but rare cases of myocarditis have been reported after COVID-19 vaccinations.Methods:
We performed a systematic literature search on PUBMED, MEDLINE, EMBASE, and Cochrane Reviews database from inception to July 18, 2021. Studies were analyzed based on predetermined eligibility criteria.Results:
A total of 19 studies containing 73 cases of COVID-19 vaccine-associated myocarditis were catalogued. Mean age was 25 years, and male to female ratio was 171. For 87.7% of patients, myocarditis occurred after the second dose. Average time to onset and length of hospitalization were 3.5 days and 5.2 days, respectively. Prognosis was benign with 100% recovery. Chest pain (100%);elevation of troponin (100%) and CRP (94.4%);and ST elevation on EKG (81.4%) were common. NSAIDs (73.5%) were the most used medication, followed by colchicine (50%).Conclusions:
Patients with COVID-19 vaccine-associated myocarditis are usually younger males presenting with chest pain 3.5 days after receiving their second dose. Work-up typically shows elevation of troponin and CRP with ST changes in EKG. Diagnosis is made after excluding all other etiologies. Given significant population benefit from COVID-19 vaccination, physicians should continue to encourage vaccination while remaining vigilant of the very rare occurrence of myocarditis following COVID-19 vaccination. [Formula presented]
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Case report
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Vaccines
Language:
English
Journal:
JACC: Cardiovascular Interventions
Year:
2022
Document Type:
Article
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