The basement membrane in the cross-roads between the lung and kidney.
Matrix Biol
; 105: 31-52, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1757644
ABSTRACT
The basement membrane (BM) is a specialized layer of extracellular matrix components that plays a central role in maintaining lung and kidney functions. Although the composition of the BM is usually tissue specific, the lung and the kidney preferentially use similar BM components. Unsurprisingly, diseases with BM defects often have severe pulmonary or renal manifestations, sometimes both. Excessive remodeling of the BM, which is a hallmark of both inflammatory and fibrosing diseases in the lung and the kidney, can lead to the release of BM-derived matrikines, proteolytic fragments with distinct biological functions. These matrikines can then influence disease activity at the site of liberation. However, they are also released to the circulation, where they can directly affect the vascular endothelium or target other organs, leading to extrapulmonary or extrarenal manifestations. In this review, we will summarize the current knowledge of the composition and function of the BM and its matrikines in health and disease, both in the lung and in the kidney. By comparison, we will highlight, why the BM and its matrikines may be central in establishing a renal-pulmonary interaction axis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Kidney
/
Lung
Type of study:
Randomized controlled trials
Language:
English
Journal:
Matrix Biol
Journal subject:
Molecular Biology
/
Biochemistry
Year:
2022
Document Type:
Article
Affiliation country:
J.matbio.2021.11.003
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