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SARS-CoV-2 RNA polymerase as target for antiviral therapy.
Buonaguro, Luigi; Tagliamonte, Maria; Tornesello, Maria Lina; Buonaguro, Franco M.
  • Buonaguro L; Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Via Mariano Semmola, 52, 80131, Naples, Italy. l.buonaguro@istitutotumori.na.it.
  • Tagliamonte M; Innovative Immunological Models, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, Via Mariano Semmola, 52, 80131, Naples, Italy.
  • Tornesello ML; Laboratory of Molecular Biology and Viral Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, 80131, Naples, Italy.
  • Buonaguro FM; Laboratory of Molecular Biology and Viral Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Pascale"-IRCCS, 80131, Naples, Italy.
J Transl Med ; 18(1): 185, 2020 05 05.
Article in English | MEDLINE | ID: covidwho-175840
ABSTRACT
A new human coronavirus named SARS-CoV-2 was identified in several cases of acute respiratory syndrome in Wuhan, China in December 2019. On March 11 2020, WHO declared the SARS-CoV-2 infection to be a pandemic, based on the involvement of 169 nations. Specific drugs for SARS-CoV-2 are obviously not available. Currently, drugs originally developed for other viruses or parasites are currently in clinical trials based on empiric data. In the quest of an effective antiviral drug, the most specific target for an RNA virus is the RNA-dependent RNA-polymerase (RdRp) which shows significant differences between positive-sense and negative-sense RNA viruses. An accurate evaluation of RdRps from different viruses may guide the development of new drugs or the repositioning of already approved antiviral drugs as treatment of SARS-CoV-2. This can accelerate the containment of the SARS-CoV-2 pandemic and, hopefully, of future pandemics due to other emerging zoonotic RNA viruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / RNA-Dependent RNA Polymerase / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02355-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / RNA-Dependent RNA Polymerase / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02355-3