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The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection.
Møhlenberg, Michelle; Monrad, Ida; Vibholm, Line K; Nielsen, Stine S F; Frattari, Giacomo Schmidt; Schleimann, Mariane Høgsbjerg; Olesen, Rikke; Kjolby, Mads; Gunst, Jesper Damsgaard; Søgaard, Ole Schmeltz; O'Brien, Thomas R; Tolstrup, Martin; Hartmann, Rune.
  • Møhlenberg M; Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.
  • Monrad I; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Vibholm LK; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Nielsen SSF; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Frattari GS; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Schleimann MH; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Olesen R; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Kjolby M; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
  • Gunst JD; DANDRITE, Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark.
  • Søgaard OS; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aalborg, Denmark.
  • O'Brien TR; University of Dundee, Scotland, United Kingdom.
  • Tolstrup M; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
  • Hartmann R; Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
J Interferon Cytokine Res ; 41(11): 407-414, 2021 11.
Article in English | MEDLINE | ID: covidwho-1758604
ABSTRACT
Genetic polymorphisms at the IFNL4 loci are known to influence the clinical outcome of several different infectious diseases. Best described is the association between the IFNL4 genotype and hepatitis C virus clearance. However, an influence of the IFNL4 genotype on the adaptive immune system was suggested by several studies but never investigated in humans. In this cross-sectional study, we have genotyped 201 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive participants for 3 IFNL4 polymorphisms (rs368234815, rs12979860, and rs117648444) and stratified them according to the IFNλ4 activity. Based on this stratification, we investigated the association between the IFNL4 genotype and the antibody as well as the CD8+ T cell response in the acute phase of the SARS-CoV-2 infection. We observed no differences in the genotype distribution compared with a Danish reference cohort or the 1,000 Genome Project, and we were not able to link the IFNL4 genotype to changes in either the antibody or CD8+ T cell responses of these patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukins / Adaptive Immunity / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Interferon Cytokine Res Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: Jir.2021.0106

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukins / Adaptive Immunity / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Interferon Cytokine Res Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: Jir.2021.0106