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Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination.
Rieke, Gereon J; van Bremen, Kathrin; Bischoff, Jenny; ToVinh, Michael; Monin, Malte B; Schlabe, Stefan; Raabe, Jan; Kaiser, Kim M; Finnemann, Claudia; Odainic, Alexandru; Kudaliyanage, Anushka; Latz, Eicke; Strassburg, Christian P; Boesecke, Christoph; Schmidt, Susanne V; Krämer, Benjamin; Rockstroh, Jürgen K; Nattermann, Jacob.
  • Rieke GJ; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • van Bremen K; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Bischoff J; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • ToVinh M; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Monin MB; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Schlabe S; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Raabe J; German Centre for Infection Research, Partner-site Cologne-Bonn, Bonn, Germany.
  • Kaiser KM; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Finnemann C; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Odainic A; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Kudaliyanage A; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
  • Latz E; Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
  • Strassburg CP; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
  • Boesecke C; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
  • Schmidt SV; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Krämer B; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.
  • Rockstroh JK; German Centre for Infection Research, Partner-site Cologne-Bonn, Bonn, Germany.
  • Nattermann J; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.
J Infect Dis ; 225(10): 1688-1693, 2022 05 16.
Article in English | MEDLINE | ID: covidwho-1853095
ABSTRACT
We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis