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Neurological outcomes 1 year after COVID-19 diagnosis: A prospective longitudinal cohort study.
Rass, Verena; Beer, Ronny; Schiefecker, Alois Josef; Lindner, Anna; Kofler, Mario; Ianosi, Bogdan Andrei; Mahlknecht, Philipp; Heim, Beatrice; Peball, Marina; Carbone, Federico; Limmert, Victoria; Kindl, Philipp; Putnina, Lauma; Fava, Elena; Sahanic, Sabina; Sonnweber, Thomas; Löscher, Wolfgang N; Wanschitz, Julia V; Zamarian, Laura; Djamshidian, Atbin; Tancevski, Ivan; Weiss, Günter; Bellmann-Weiler, Rosa; Kiechl, Stefan; Seppi, Klaus; Loeffler-Ragg, Judith; Pfausler, Bettina; Helbok, Raimund.
  • Rass V; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Beer R; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Schiefecker AJ; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Lindner A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kofler M; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Ianosi BA; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Mahlknecht P; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Heim B; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Peball M; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Carbone F; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Limmert V; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kindl P; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Putnina L; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Fava E; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Sahanic S; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Sonnweber T; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Löscher WN; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Wanschitz JV; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Zamarian L; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Djamshidian A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Tancevski I; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Weiss G; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Bellmann-Weiler R; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Kiechl S; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Seppi K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Loeffler-Ragg J; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Pfausler B; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Helbok R; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Eur J Neurol ; 29(6): 1685-1696, 2022 06.
Article in English | MEDLINE | ID: covidwho-1759178
ABSTRACT
BACKGROUND AND

PURPOSE:

Neurological sequelae from coronavirus disease 2019 (COVID-19) may persist after recovery from acute infection. Here, the aim was to describe the natural history of neurological manifestations over 1 year after COVID-19.

METHODS:

A prospective, multicentre, longitudinal cohort study in COVID-19 survivors was performed. At a 3-month and 1-year follow-up, patients were assessed for neurological impairments by a neurological examination and a standardized test battery including the assessment of hyposmia (16-item Sniffin' Sticks test), cognitive deficits (Montreal Cognitive Assessment < 26) and mental health (Hospital Anxiety and Depression Scale and Post-traumatic Stress Disorder Checklist 5).

RESULTS:

Eighty-one patients were evaluated 1 year after COVID-19, out of which 76 (94%) patients completed a 3-month and 1-year follow-up. Patients were 54 (47-64) years old and 59% were male. New and persistent neurological disorders were found in 15% (3 months) and 12% (10/81; 1 year). Symptoms at 1-year follow-up were reported by 48/81 (59%) patients, including fatigue (38%), concentration difficulties (25%), forgetfulness (25%), sleep disturbances (22%), myalgia (17%), limb weakness (17%), headache (16%), impaired sensation (16%) and hyposmia (15%). Neurological examination revealed findings in 52/81 (64%) patients without improvement over time (3 months, 61%, p = 0.230) including objective hyposmia (Sniffin' Sticks test <13; 51%). Cognitive deficits were apparent in 18%, whereas signs of depression, anxiety and post-traumatic stress disorders were found in 6%, 29% and 10% respectively 1 year after infection. These mental and cognitive disorders had not improved after the 3-month follow-up (all p > 0.05).

CONCLUSION:

Our data indicate that a significant patient number still suffer from neurological sequelae including neuropsychiatric symptoms 1 year after COVID-19 calling for interdisciplinary management of these patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: Ene.15307

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Topics: Long Covid Limits: Female / Humans / Male / Middle aged Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: Ene.15307