Acute Kidney Injury in SARS-CoV-2 Infection: Direct Effect of Virus on Kidney Proximal Tubule Cells.

Soleimani, Manoocher

Soleimani, Manoocher.

Soleimani M; Medicine and Research Services, VA Medical Center, Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87106, USA.

Int J Mol Sci ; 21(9)2020 May 05.

Article in English | MEDLINE | ID: covidwho-175942

ABSTRACT

ABSTRACT

Coronaviruses (CoVs), including Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and the novel coronavirus disease-2 (SARS-CoV-2) are a group of enveloped RNA viruses that cause a severe respiratory infection which is associated with a high mortality [...].

Subject(s)

Acute Kidney Injury/mortality; Acute Kidney Injury/virology; Betacoronavirus/pathogenicity; Coronavirus Infections/virology; Kidney Tubules, Proximal/metabolism; Kidney Tubules, Proximal/virology; Pneumonia, Viral/virology; Acute Kidney Injury/physiopathology; Acute Kidney Injury/prevention & control; Angiotensin II/pharmacology; Angiotensin-Converting Enzyme 2; COVID-19; Cathepsins/metabolism; Cell Death/drug effects; Coronavirus Infections/mortality; Coronavirus Infections/pathology; Coronavirus Infections/physiopathology; Creatinine/blood; Critical Illness/mortality; Endosomes/drug effects; Endosomes/enzymology; Endosomes/metabolism; Humans; Hydrogen-Ion Concentration; Incidence; Kidney Tubules, Proximal/physiopathology; Lysosomes/drug effects; Lysosomes/enzymology; Lysosomes/metabolism; Pandemics; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/mortality; Pneumonia, Viral/pathology; Pneumonia, Viral/physiopathology; Receptors, Virus/metabolism; SARS-CoV-2; Severe Acute Respiratory Syndrome/blood; Severe Acute Respiratory Syndrome/mortality; Severe Acute Respiratory Syndrome/physiopathology; Virus Internalization; Virus Replication

Keywords

ACE2; SARS-CoV-2; acute kidney injury; lysosomes; proximal tubule cells

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Acute Kidney Injury / Betacoronavirus / Kidney Tubules, Proximal Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2020 Document Type: Article Affiliation country: IJMS21093275

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