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Better, Faster, Cheaper: Recent Advances in Cryo-Electron Microscopy.
Chua, Eugene Y D; Mendez, Joshua H; Rapp, Micah; Ilca, Serban L; Tan, Yong Zi; Maruthi, Kashyap; Kuang, Huihui; Zimanyi, Christina M; Cheng, Anchi; Eng, Edward T; Noble, Alex J; Potter, Clinton S; Carragher, Bridget.
  • Chua EYD; New York Structural Biology Center, New York, NY, USA; email: echua@nysbc.org, jmendez@nysbc.org, mrapp@nysbc.org, silca@nysbc.org, kmaruthi@nysbc.org, hkuang@nysbc.org, czimanyi@nysbc.org, acheng@nysbc.org, eeng@nysbc.org, anoble@nysbc.org, cpotter@nysbc.org, bcarr@nysbc.org.
  • Mendez JH; Simons Electron Microscopy Center, New York, NY, USA.
  • Rapp M; National Center for CryoEM Access and Training, New York, NY, USA.
  • Ilca SL; New York Structural Biology Center, New York, NY, USA; email: echua@nysbc.org, jmendez@nysbc.org, mrapp@nysbc.org, silca@nysbc.org, kmaruthi@nysbc.org, hkuang@nysbc.org, czimanyi@nysbc.org, acheng@nysbc.org, eeng@nysbc.org, anoble@nysbc.org, cpotter@nysbc.org, bcarr@nysbc.org.
  • Tan YZ; Simons Electron Microscopy Center, New York, NY, USA.
  • Maruthi K; National Center for CryoEM Access and Training, New York, NY, USA.
  • Kuang H; New York Structural Biology Center, New York, NY, USA; email: echua@nysbc.org, jmendez@nysbc.org, mrapp@nysbc.org, silca@nysbc.org, kmaruthi@nysbc.org, hkuang@nysbc.org, czimanyi@nysbc.org, acheng@nysbc.org, eeng@nysbc.org, anoble@nysbc.org, cpotter@nysbc.org, bcarr@nysbc.org.
  • Zimanyi CM; Simons Electron Microscopy Center, New York, NY, USA.
  • Cheng A; New York Structural Biology Center, New York, NY, USA; email: echua@nysbc.org, jmendez@nysbc.org, mrapp@nysbc.org, silca@nysbc.org, kmaruthi@nysbc.org, hkuang@nysbc.org, czimanyi@nysbc.org, acheng@nysbc.org, eeng@nysbc.org, anoble@nysbc.org, cpotter@nysbc.org, bcarr@nysbc.org.
  • Eng ET; Simons Electron Microscopy Center, New York, NY, USA.
  • Noble AJ; Department of Biological Sciences, National University of Singapore, Singapore; email: yztan@nus.edu.sg.
  • Potter CS; Disease Intervention Technology Laboratory, Agency for Science, Technology and Research (A*STAR), Singapore.
  • Carragher B; New York Structural Biology Center, New York, NY, USA; email: echua@nysbc.org, jmendez@nysbc.org, mrapp@nysbc.org, silca@nysbc.org, kmaruthi@nysbc.org, hkuang@nysbc.org, czimanyi@nysbc.org, acheng@nysbc.org, eeng@nysbc.org, anoble@nysbc.org, cpotter@nysbc.org, bcarr@nysbc.org.
Annu Rev Biochem ; 91: 1-32, 2022 06 21.
Article in English | MEDLINE | ID: covidwho-1759478
ABSTRACT
Cryo-electron microscopy (cryo-EM) continues its remarkable growth as a method for visualizing biological objects, which has been driven by advances across the entire pipeline. Developments in both single-particle analysis and in situ tomography have enabled more structures to be imaged and determined to better resolutions, at faster speeds, and with more scientists having improved access. This review highlights recent advances at each stageof the cryo-EM pipeline and provides examples of how these techniques have been used to investigate real-world problems, including antibody development against the SARS-CoV-2 spike during the recent COVID-19 pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Limits: Humans Language: English Journal: Annu Rev Biochem Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Limits: Humans Language: English Journal: Annu Rev Biochem Year: 2022 Document Type: Article