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The effects of high dose vitamin D supplementation as a nutritional intervention strategy on biochemical and inflammatory factors in adults with COVID-19: Study protocol for a randomized controlled trial.
Khorasanchi, Zahra; Jafazadeh Esfehani, Ali; Sharifan, Payam; Hasanzadeh, Elahe; Shadmand Foumani Moghadam, Mohammad Reza; Ahmadi, Omid; Ebrahimi, Reyhaneh; Lotfi, Seyede Zahra; Milani, Nasrin; Mozdourian, Mahnaz; Rezvani, Reza; Vatanparast, Hasan; Assaran Darban, Reza; Ferns, Gordon; Ghayour Mobarhan, Majid.
  • Khorasanchi Z; Department of Nutrition, School of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Jafazadeh Esfehani A; Student Research Committee, Faculty of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sharifan P; Metabolic Syndrome Research Center, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hasanzadeh E; Department of Nutrition, School of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Shadmand Foumani Moghadam MR; International UNESCO center for Health Related Basic Sciences and Human Nutrition, Department of Nutrition, Faculty of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ahmadi O; Varastegan Institute for Medical Sciences, Mashhad, Iran.
  • Ebrahimi R; Department of Parasitology and Mycology, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran.
  • Lotfi SZ; International UNESCO center for Health Related Basic Sciences and Human Nutrition, Department of Nutrition, Faculty of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Milani N; Kidney Transplantation Complication Research Center, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mozdourian M; Department of Internal Medicine, Faculty of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Rezvani R; Lung Diseases Research Center, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Vatanparast H; Department of Nutrition, School of Medicine, 37552Mashhad University of Medical Sciences, Mashhad, Iran.
  • Assaran Darban R; College of Pharmacy and Nutrition, 7235University of Saskatchewan, Health Sciences E-Wing, Saskatoon, Saskatchewan, Canada.
  • Ferns G; Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
  • Ghayour Mobarhan M; Division of Medical Education, Brighton and Sussex Medical School, Brighton, UK.
Nutr Health ; 28(3): 311-317, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1759615
ABSTRACT

Introduction:

Low serum vitamin D has been shown to be a risk factor for Coronavirus 2019 (COVID-19). The aim of this study was to assess the effects of high dose vitamin D supplementation on hs-CRP, ESR and clinical outcomes, including duration of hospitalization, quality of life and New York Heart Association (NYHA) Functional Classification, in adults with COVID-19.

Methods:

This double-blind, randomized control trial will be conducted on patients with RT-PCR and/or chest CT scan diagnosis of COVID-19 admitted in Imam Reza Hospital, Mashhad, Iran. Participants will be randomized into control and intervention groups based on randomization sampling. The intervention group will receive soft gel containing 50,000 IU vitamin D on the first day followed by 10,000 IU/day through a supplement drop daily for 29 days. The control group will receive 1000 IU vitamin D daily through supplement drop and a placebo soft gel. All participants will undergo laboratory assessment including inflammatory markers, serum 25)OH)D, complete blood count (CBC), liver and renal profile, lipid profile and erythrocyte sedimentation rate (ESR) at baseline and at day 30. The mortality rate will be recorded in both groups.

Results:

Data will be presented using descriptive statistics. Comparison of changes in study parameters over the study period will be performed using analysis of covariance adjusting for possible confounders.

Conclusions:

The findings of this will provide evidence on the effects of high dose vitamin D supplementation on inflammatory markers in hospitalized COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D Deficiency / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Adult / Humans Language: English Journal: Nutr Health Year: 2022 Document Type: Article Affiliation country: 02601060221082384

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D Deficiency / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Traditional medicine Limits: Adult / Humans Language: English Journal: Nutr Health Year: 2022 Document Type: Article Affiliation country: 02601060221082384