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Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2.
Rosas Mejia, Oscar; Gloag, Erin S; Li, Jianying; Ruane-Foster, Marisa; Claeys, Tiffany A; Farkas, Daniela; Wang, Shu-Hua; Farkas, Laszlo; Xin, Gang; Robinson, Richard T.
  • Rosas Mejia O; Department of Microbial Infection and Immunity.
  • Gloag ES; Department of Microbial Infection and Immunity.
  • Li J; Pelotonia Institute for Immuno-Oncology.
  • Ruane-Foster M; Department of Microbial Infection and Immunity.
  • Claeys TA; Department of Microbial Infection and Immunity.
  • Farkas D; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute.
  • Wang SH; Department of Infectious Disease, The Ohio State University, Columbus, Ohio, United States of America.
  • Farkas L; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute.
  • Xin G; Department of Microbial Infection and Immunity.
  • Robinson RT; Pelotonia Institute for Immuno-Oncology.
PLoS Pathog ; 18(3): e1010093, 2022 03.
Article in English | MEDLINE | ID: covidwho-1759969
ABSTRACT
Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal respiratory infections, the effect of Mtb infection and its associated immune response on secondary infection with CoV2 is unknown. To address this question we applied two mouse models of COVID19, using mice which were chronically infected with Mtb. In both model systems, Mtb-infected mice were resistant to the pathological consequences of secondary CoV2 infection, and CoV2 infection did not affect Mtb burdens. Single cell RNA sequencing of coinfected and monoinfected lungs demonstrated the resistance of Mtb-infected mice is associated with expansion of T and B cell subsets upon viral challenge. Collectively, these data demonstrate that Mtb infection conditions the lung environment in a manner that is not conducive to CoV2 survival.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coinfection / COVID-19 / Mycobacterium tuberculosis Type of study: Prognostic study Limits: Animals Language: English Journal: PLoS Pathog Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coinfection / COVID-19 / Mycobacterium tuberculosis Type of study: Prognostic study Limits: Animals Language: English Journal: PLoS Pathog Year: 2022 Document Type: Article