Pathogenic Exploitation of Lymphatic Vessels.
Cells
; 11(6)2022 03 12.
Article
in English
| MEDLINE | ID: covidwho-1760408
ABSTRACT
Lymphatic vessels provide a critical line of communication between peripheral tissues and their draining lymph nodes, which is necessary for robust immune responses against infectious agents. At the same time, lymphatics help shape the nature and kinetics of immune responses to ensure resolution, limit tissue damage, and prevent autoimmune responses. A variety of pathogens have developed strategies to exploit these functions, from multicellular organisms like nematodes to bacteria, viruses, and prions. While lymphatic vessels serve as transport routes for the dissemination of many pathogens, their hypoxic and immune-suppressive environments can provide survival niches for others. Lymphatics can be exploited as perineural niches, for inter-organ distribution among highly motile carrier cells, as effective replicative niches, and as alternative routes in response to therapy. Recent studies have broadened our understanding of lymphatic involvement in pathogenic spread to include a wider range of pathogens, as well as new mechanisms of exploitation, which we summarize here.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Lymphatic Vessels
/
Lymph Nodes
Type of study:
Prognostic study
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Cells11060979
Similar
MEDLINE
...
LILACS
LIS