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Genetic Therapy and Molecular Targeted Therapy in Oncology: Safety, Pharmacovigilance, and Perspectives for Research and Clinical Practice.
Orzetti, Sabrina; Tommasi, Federica; Bertola, Antonella; Bortolin, Giorgia; Caccin, Elisabetta; Cecco, Sara; Ferrarin, Emanuela; Giacomin, Elisa; Baldo, Paolo.
  • Orzetti S; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Tommasi F; Department of Hospital Pharmacy, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), 33100 Udine, Italy.
  • Bertola A; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Bortolin G; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Caccin E; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Cecco S; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Ferrarin E; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Giacomin E; Scientific and Patients Library of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
  • Baldo P; Hospital Pharmacy Unit of the "Centro di Riferimento Oncologico (CRO) di Aviano IRCCS", Via F. Gallini, 33081 Aviano, Italy.
Int J Mol Sci ; 23(6)2022 Mar 10.
Article in English | MEDLINE | ID: covidwho-1760646
ABSTRACT
The impressive advances in the knowledge of biomarkers and molecular targets has enabled significant progress in drug therapy for crucial diseases such as cancer. Specific areas of pharmacology have contributed to these therapeutic outcomes-mainly targeted therapy, immunomodulatory therapy, and gene therapy. This review focuses on the pharmacological profiles of these therapeutic classes and intends, on the one hand, to provide a systematic definition and, on the other, to highlight some aspects related to pharmacovigilance, namely the monitoring of safety and the identification of potential toxicities and adverse drug reactions. Although clinicians often consider pharmacovigilance a non-priority area, it highlights the risk/benefit ratio, an essential factor, especially for these advanced therapies, which represent the most innovative and promising horizon in oncology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions / Antineoplastic Agents Type of study: Prognostic study / Systematic review/Meta Analysis Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23063012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug-Related Side Effects and Adverse Reactions / Antineoplastic Agents Type of study: Prognostic study / Systematic review/Meta Analysis Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23063012