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Effect of Short Time of SARS-CoV-2 Infection in Caco-2 Cells
Viruses ; 14(4):704, 2022.
Article in English | MDPI | ID: covidwho-1762765
ABSTRACT
Coronavirus disease 19 (COVID-19) clinical manifestations include the involvement of the gastrointestinal tract, affecting around 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children. In the present work, the consequence of a short time of viral absorption (5, 15, 30 and 60 min) was tested on the Caco-2 intestinal epithelial cell line. Our findings show that Caco-2 cells are highly permissive to SARS-CoV-2 infection, even after 5 min of viral inoculation at a multiplicity of infection of 0.1. No cytopathic effect was evident during the subsequent 7 days of monitoring;nevertheless, the immunofluorescence staining for the viral nucleocapsid confirmed the presence of intracellular SARS-CoV-2. Our findings highlight the very short time during which SARS-CoV-2 is able to infect these cells in vitro.
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Collection: Databases of international organizations Database: MDPI Type of study: Experimental Studies Language: English Journal: Viruses Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: MDPI Type of study: Experimental Studies Language: English Journal: Viruses Year: 2022 Document Type: Article