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Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer.
Fu, Julie; Reid, Sonya A; French, Benjamin; Hennessy, Cassandra; Hwang, Clara; Gatson, Na Tosha; Duma, Narjust; Mishra, Sanjay; Nguyen, Ryan; Hawley, Jessica E; Singh, Sunny R K; Chism, David D; Venepalli, Neeta K; Warner, Jeremy L; Choueiri, Toni K; Schmidt, Andrew L; Fecher, Leslie A; Girard, Jennifer E; Bilen, Mehmet A; Ravindranathan, Deepak; Goyal, Sharad; Wise-Draper, Trisha M; Park, Cathleen; Painter, Corrie A; McGlown, Sheila M; de Lima Lopes, Gilberto; Serrano, Oscar K; Shah, Dimpy P.
  • Fu J; Department of Internal Medicine, Hematology-Oncology, Tufts Medical Center Cancer Center, Stoneham, Massachusetts.
  • Reid SA; Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  • French B; Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, Tennessee.
  • Hennessy C; Department of Biostatistics, Vanderbilt University, Nashville, Tennessee.
  • Hwang C; Department of Biostatistics, Vanderbilt University, Nashville, Tennessee.
  • Gatson NT; Department of Internal Medicine, Division of Hematology-Oncology, Henry Ford Cancer Institute, Detroit, Michigan.
  • Duma N; Geisinger Health System, Danville, Danville, Pennsylvania.
  • Mishra S; Department of Cancer Medicine, Division of Neuro-Oncology, Banner MD Anderson Cancer Center, Gilbert, Arizona.
  • Nguyen R; Division of Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Hawley JE; Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, Tennessee.
  • Singh SRK; Department of Hematology and Oncology, University of Illinois, Chicago.
  • Chism DD; Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York.
  • Venepalli NK; Now with Division of Oncology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle.
  • Warner JL; Department of Internal Medicine, Division of Hematology-Oncology, Henry Ford Cancer Institute, Detroit, Michigan.
  • Choueiri TK; Thompson Cancer Survival Center, Knoxville, Tennessee.
  • Schmidt AL; Division of Oncology, Department of Medicine, University of North Carolina, Chapel Hill.
  • Fecher LA; Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  • Girard JE; Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, Tennessee.
  • Bilen MA; Department of Biomedical Informatics, Vanderbilt University, Nashville, Tennessee.
  • Ravindranathan D; Division of Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Goyal S; Division of Medical Oncology, Department of Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Wise-Draper TM; Rogel Cancer Center, University of Michigan, Ann Arbor.
  • Park C; Rogel Cancer Center, University of Michigan, Ann Arbor.
  • Painter CA; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
  • McGlown SM; Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia.
  • de Lima Lopes G; Department of Radiation Oncology, George Washington University, Washington, DC.
  • Serrano OK; Department of Internal Medicine, Division of Hematology-Oncology, University of Cincinnati Cancer Center, Cincinnati, Ohio.
  • Shah DP; Department of Hematology-Oncology, University of California, Davis.
JAMA Netw Open ; 5(3): e224304, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1763163
ABSTRACT
Importance Non-Hispanic Black individuals experience a higher burden of COVID-19 than the general population; hence, there is an urgent need to characterize the unique clinical course and outcomes of COVID-19 in Black patients with cancer.

Objective:

To investigate racial disparities in severity of COVID-19 presentation, clinical complications, and outcomes between Black patients and non-Hispanic White patients with cancer and COVID-19. Design, Setting, and

Participants:

This retrospective cohort study used data from the COVID-19 and Cancer Consortium registry from March 17, 2020, to November 18, 2020, to examine the clinical characteristics and outcomes of COVID-19 in Black patients with cancer. Data analysis was performed from December 2020 to February 2021. Exposures Black and White race recorded in patient's electronic health record. Main Outcomes and

Measures:

An a priori 5-level ordinal scale including hospitalization intensive care unit admission, mechanical ventilation, and all-cause death.

Results:

Among 3506 included patients (1768 women [50%]; median [IQR] age, 67 [58-77] years), 1068 (30%) were Black and 2438 (70%) were White. Black patients had higher rates of preexisting comorbidities compared with White patients, including obesity (480 Black patients [45%] vs 925 White patients [38%]), diabetes (411 Black patients [38%] vs 574 White patients [24%]), and kidney disease (248 Black patients [23%] vs 392 White patients [16%]). Despite the similar distribution of cancer type, cancer status, and anticancer therapy at the time of COVID-19 diagnosis, Black patients presented with worse illness and had significantly worse COVID-19 severity (unweighted odds ratio, 1.34 [95% CI, 1.15-1.58]; weighted odds ratio, 1.21 [95% CI, 1.11-1.33]). Conclusions and Relevance These findings suggest that Black patients with cancer experience worse COVID-19 outcomes compared with White patients. Understanding and addressing racial inequities within the causal framework of structural racism is essential to reduce the disproportionate burden of diseases, such as COVID-19 and cancer, in Black patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans Language: English Journal: JAMA Netw Open Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Female / Humans Language: English Journal: JAMA Netw Open Year: 2022 Document Type: Article