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Oncologist counseling practice and COVID-19 vaccination outcomes for patients with history of PEG-asparaginase hypersensitivity.
Zarnegar-Lumley, Sara; Stone, Cosby A; Smith, Christine M; Hall, Laura L; Luck, Kate E; Koo, Grace; Plager, Jessica H; Phillips, Elizabeth J; Friedman, Debra L.
  • Zarnegar-Lumley S; Division of Hematology and Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Stone CA; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Smith CM; Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Hall LL; Division of Hematology and Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Luck KE; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Koo G; Department of Pediatric Pharmacy, Pharmacology, Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
  • Plager JH; Division of Hematology and Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Phillips EJ; Department of Pediatric Pharmacy, Pharmacology, Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
  • Friedman DL; Department of Pediatric Pharmacy, Pharmacology, Monroe Carell, Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee, USA.
Pediatr Blood Cancer ; 69(7): e29686, 2022 07.
Article in English | MEDLINE | ID: covidwho-1763274
ABSTRACT
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective strategy to prevent serious coronavirus disease 2019 (COVID-19) and is important for oncology patients. mRNA-based COVID-19 vaccines are contraindicated in those with a history of severe or immediate allergy to any vaccine component, including polyethylene glycol (PEG)2000. Patients with acute lymphoblastic leukemia/lymphoma receive asparaginase conjugated to PEG5000 (PEG-ASNase) and those with PEG-ASNase-associated hypersensitivity may be unnecessarily excluded from receiving mRNA COVID-19 vaccines. We, therefore, surveyed oncologists on COVID-19 vaccine counseling practice and vaccination outcomes in COVID-19 vaccination-eligible patients and show safe receipt of mRNA vaccines despite PEG-ASNase hypersensitivity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyethylene Glycols / Asparaginase / Drug Hypersensitivity / COVID-19 Vaccines / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2022 Document Type: Article Affiliation country: Pbc.29686

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polyethylene Glycols / Asparaginase / Drug Hypersensitivity / COVID-19 Vaccines / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2022 Document Type: Article Affiliation country: Pbc.29686