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Clinical monitored in subjects metabolically healthy and unhealthy before and during a SARS-CoV-2 infection- A cross-sectional study in Mexican population.
Treviño, Samuel; Cortezano-Esteban, Steffany; Hernández-Fragoso, Hugo; Díaz, Alfonso; Vázquez-Roque, Rubén; Enrique Sarmiento-Ortega, Victor; Moroni-González, Diana; Pelayo, Rosana; Brambila, Eduardo.
  • Treviño S; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla. 14 South. FCQ1, University City, Puebla, C.P. 72560, Mexico; Clinical Laboratory "Los Ángeles, Endocrinology area, rio Nexapa 6153, col. San Manuel, Puebla
  • Cortezano-Esteban S; Clinical Laboratory "Los Ángeles, Endocrinology area, rio Nexapa 6153, col. San Manuel, Puebla, C.P. 72560, Mexico.
  • Hernández-Fragoso H; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla. 14 South. FCQ1, University City, Puebla, C.P. 72560, Mexico; Clinical Laboratory "Los Ángeles, Endocrinology area, rio Nexapa 6153, col. San Manuel, Puebla
  • Díaz A; Department of Pharmacy, Faculty of Chemistry Science, University Autonomous of Puebla. 22 South. FCQ9, University City, Puebla, C.P. 72560, Mexico.
  • Vázquez-Roque R; Neuropsychiatry laboratory, Physiology Institute, University Autonomous of Puebla. 14 South. University City, Puebla, C.P. 72560, Mexico.
  • Enrique Sarmiento-Ortega V; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla. 14 South. FCQ1, University City, Puebla, C.P. 72560, Mexico.
  • Moroni-González D; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla. 14 South. FCQ1, University City, Puebla, C.P. 72560, Mexico.
  • Pelayo R; Eastern Biomedical Research Center CIBIOR, Mexican Institute for Social Security, Puebla, Mexico.
  • Brambila E; Laboratory of Chemical-Clinical Investigations, Department of Clinical Chemistry, Faculty of Chemistry Science, University Autonomous of Puebla. 14 South. FCQ1, University City, Puebla, C.P. 72560, Mexico.
Cytokine ; 153: 155868, 2022 05.
Article in English | MEDLINE | ID: covidwho-1763681
ABSTRACT
The COVID-19 disease has forced us to consider the physiologic role of obesity and metabolically healthy and unhealthy status in response to SARS-CoV-2 infection. Hematological, coagulation, biochemical, and immunoinflammatory changes have been informed with a disparity in morbidity and mortality. Therefore, we aimed to investigate the influence of metabolic health on clinical features in a cross-sectional study in Mexican subjects with and without SARS-CoV-2 infection in non-severe stages after a rigorous classification of obese and non-obese subjects who were metabolically healthy and unhealthy. Four groups were formed 1) metabolically healthy with normal BMI (MHN); 2) metabolically unhealthy with normal BMI (MUN); 3) metabolically healthy obese (MHO); 4) metabolically unhealthy obese (MUO). Serum proinflammatory (TNF-α, MCP-1, IL-1ß, and IL-6) and anti-inflammatory (TGF-ß, IL-1Ra, IL-4, and IL-10) cytokines, hematological parameters, coagulation, and acute phase components were evaluated. Our results showed that MHO people live with inflammaging. Meanwhile, MUN and MUO subjects develop metaflammation. Both inflammaging and metaflammation cause imperceptible modifications on hematological parameters, mainly in leukocyte populations and platelets, as well as acute phase and coagulation components. The statistical analysis revealed that many clinical features are dependent on metabolic health. In conclusion, MHO subjects seem to be transitioning from metabolically healthy to unhealthy, which is accelerated in acute processes, such as SARS-CoV-2 infection. Meanwhile, metabolically unhealthy subjects independently of BMI have a deteriorating immunometabolic status associated with a hyperinflammatory state leading to multi-organ dysfunction, treatment complications, and severe COVID-19 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Metabolic Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Mexico Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Metabolic Syndrome / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Mexico Language: English Journal: Cytokine Journal subject: Allergy and Immunology Year: 2022 Document Type: Article