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Guillain-Barré syndrome: expanding the concept of molecular mimicry.
Laman, Jon D; Huizinga, Ruth; Boons, Geert-Jan; Jacobs, Bart C.
  • Laman JD; Department of Pathology and Medical Biology, University of Groningen, UMC Groningen and MS Center Northern Netherlands (MSCNN), Groningen, The Netherlands. Electronic address: j.d.laman@umcg.nl.
  • Huizinga R; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Boons GJ; Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602-4712, USA; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 Utrecht, The Netherlands; Bijvoet Center for Biomolecular Research, Utrecht University,
  • Jacobs BC; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: b.jacobs@erasmusmc.nl.
Trends Immunol ; 43(4): 296-308, 2022 04.
Article in English | MEDLINE | ID: covidwho-1763781
ABSTRACT
Guillain-Barré syndrome (GBS) is a rapidly progressive, monophasic, and potentially devastating immune-mediated neuropathy in humans. Preceding infections trigger the production of cross-reactive antibodies against gangliosides concentrated in human peripheral nerves. GBS is elicited by at least five distinct common bacterial and viral pathogens, speaking to the notion of polymicrobial disease causation. This opinion emphasizes that GBS is the best-supported example of true molecular mimicry at the B cell level. Moreover, we argue that mechanistically, single and multiplexed microbial carbohydrate epitopes induce IgM, IgA, and IgG subclasses in ways that challenge the classic concept of thymus-dependent (TD) versus thymus-independent (TI) antibody responses in GBS. Finally, we discuss how GBS can be exemplary for driving innovation in diagnostics and immunotherapy for other antibody-driven neurological diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Molecular Mimicry / Guillain-Barre Syndrome Type of study: Randomized controlled trials Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Molecular Mimicry / Guillain-Barre Syndrome Type of study: Randomized controlled trials Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article