Guillain-Barré syndrome: expanding the concept of molecular mimicry.
Trends Immunol
; 43(4): 296-308, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1763781
ABSTRACT
Guillain-Barré syndrome (GBS) is a rapidly progressive, monophasic, and potentially devastating immune-mediated neuropathy in humans. Preceding infections trigger the production of cross-reactive antibodies against gangliosides concentrated in human peripheral nerves. GBS is elicited by at least five distinct common bacterial and viral pathogens, speaking to the notion of polymicrobial disease causation. This opinion emphasizes that GBS is the best-supported example of true molecular mimicry at the B cell level. Moreover, we argue that mechanistically, single and multiplexed microbial carbohydrate epitopes induce IgM, IgA, and IgG subclasses in ways that challenge the classic concept of thymus-dependent (TD) versus thymus-independent (TI) antibody responses in GBS. Finally, we discuss how GBS can be exemplary for driving innovation in diagnostics and immunotherapy for other antibody-driven neurological diseases.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Molecular Mimicry
/
Guillain-Barre Syndrome
Type of study:
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Trends Immunol
Journal subject:
Allergy and Immunology
Year:
2022
Document Type:
Article
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