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Fibrosis-4 index and mortality in coronavirus disease 2019: a meta-analysis.
Pranata, Raymond; Yonas, Emir; Huang, Ian; Lim, Michael Anthonius; Nasution, Sally Aman; Kuswardhani, Raden Ayu Tuty.
  • Pranata R; Faculty of Medicine, Universitas Pelita Harapan, Tangerang.
  • Yonas E; Faculty of Medicine, Universitas YARSI, Jakarta.
  • Huang I; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung.
  • Lim MA; Faculty of Medicine, Universitas Pelita Harapan, Tangerang.
  • Nasution SA; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta.
  • Kuswardhani RAT; Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Udayana University, Sanglah Teaching Hospital, Denpasar - Bali, Indonesia.
Eur J Gastroenterol Hepatol ; 33(1S Suppl 1): e368-e374, 2021 12 01.
Article in English | MEDLINE | ID: covidwho-2276910
ABSTRACT
BACKGROUND/

AIMS:

In this meta-analysis, we aimed to evaluate the prognostic value of fibrosis-4 index (FIB-4) in COVID-19.

METHODS:

We performed a comprehensive literature search of PubMed, Embase, and Scopus databases on 26 November 2020. FIB-4 was calculated by [age (years) × AST (IU/L)]/[platelet count (109/L) × âˆšALT (U/L)]. A value above cutoff point was considered high and a value below cutoff point was considered low. The main outcome was mortality, the association between high FIB-4 and mortality was reported in odds ratio (OR). Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic OR (DOR), area under the curve (AUC) were generated.

RESULTS:

There were 963 patients from five studies included in this systematic review and meta-analysis. Meta-analysis showed that high FIB-4 was associated with increased mortality [OR 3.96 (2.16-7.27), P < 0.001; I2 41.3%]. High FIB-4 was associated mortality with a sensitivity of 0.56 (0.40-0.70), specificity of 0.80 (0.72-0.86), PLR 2.8 (1.8-4.2), NLR 0.55 (0.39-0.78), DOR 5 (2-10), and AUC of 0.77 (0.73-0.81). Fagan's nomogram indicated that for a pre-test probability (mortality) of 30%, a high FIB-4 was associated with 54% post-test probability and a low FIB-4 was associated with 19%, respectively. The funnel-plot analysis was asymmetrical, trim-and-fill analysis by imputation of a study on the left side using linear estimator resulted in an OR of 3.48 (1.97-6.14). Egger's test showed no indication of small-study effects (P = 0.881).

CONCLUSION:

High FIB-4 was associated with mortality in patients with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Eur J Gastroenterol Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Eur J Gastroenterol Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article