Associations between persistent symptoms after mild COVID-19 and long-term health status, quality of life, and psychological distress.
Influenza Other Respir Viruses
; 16(4): 680-689, 2022 07.
Article
in English
| MEDLINE | ID: covidwho-1764954
ABSTRACT
BACKGROUND:
We sought to assess whether persistent COVID-19 symptoms beyond 6 months (Long-COVID) among patients with mild COVID-19 is associated with poorer health status, quality of life, and psychological distress.METHODS:
This was a multicenter prospective cohort study that included adult outpatients with acute COVID-19 from eight sites during 2-week sampling periods from April 1 and July 28, 2020. Participants were contacted 6-11 months after their first positive SARS-CoV-2 to complete a survey, which collected information on the severity of eight COVID-19 symptoms using a 4-point scale ranging from 0 (not present) to 3 (severe) at 1 month before COVID-19 (pre-illness) and at follow-up; the difference for each was calculated as an attributable persistent symptom severity score. A total attributable persistent COVID-19 symptom burden score was calculated by summing the attributable persistent severity scores for all eight symptoms. Outcomes measured at long-term follow-up comprised overall health status (EuroQol visual analogue scale), quality of life (EQ-5D-5L), and psychological distress (Patient Health Questionnaire-4). The association between the total attributable persistent COVID-19 burden score and each outcome was analyzed using multivariable proportional odds regression.RESULTS:
Of the 2092 outpatients with COVID-19, 436 (21%) responded to the survey. The median (IQR) attributable persistent COVID-19 symptom burden score was 2 (0, 4); higher scores were associated with lower overall health status (aOR 0.63; 95% CI 0.57-0.69), lower quality of life (aOR 0.65; 95%CI 0.59-0.72), and higher psychological distress (aOR 1.40; 95%CI, 1.28-1.54) after adjusting for age, race, ethnicity, education, and income.CONCLUSIONS:
In participants with mild acute COVID-19, the burden of persistent symptoms was significantly associated with poorer long-term health status, poorer quality of life, and psychological distress.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Psychological Distress
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
Limits:
Adult
/
Humans
Language:
English
Journal:
Influenza Other Respir Viruses
Journal subject:
Virology
Year:
2022
Document Type:
Article
Affiliation country:
Irv.12980
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