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Associations between persistent symptoms after mild COVID-19 and long-term health status, quality of life, and psychological distress.
Han, Jin H; Womack, Kelsey N; Tenforde, Mark W; Files, D Clark; Gibbs, Kevin W; Shapiro, Nathan I; Prekker, Matthew E; Erickson, Heidi L; Steingrub, Jay S; Qadir, Nida; Khan, Akram; Hough, Catherine L; Johnson, Nicholas J; Ely, E Wesley; Rice, Todd W; Casey, Jonathan D; Lindsell, Christopher J; Gong, Michelle N; Srinivasan, Vasisht; Lewis, Nathaniel M; Patel, Manish M; Self, Wesley H.
  • Han JH; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Womack KN; Geriatric Research, Education, and Clinical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
  • Tenforde MW; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Files DC; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gibbs KW; Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA.
  • Shapiro NI; Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA.
  • Prekker ME; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Erickson HL; Hennepin County Medical Center, Minneapolis, Minnesota, USA.
  • Steingrub JS; Hennepin County Medical Center, Minneapolis, Minnesota, USA.
  • Qadir N; Baystate Medical Center, Springfield, Massachusetts, USA.
  • Khan A; UCLA Medical Center, Los Angeles, California, USA.
  • Hough CL; Oregon Health & Sciences University, Portland, Oregon, USA.
  • Johnson NJ; Oregon Health & Sciences University, Portland, Oregon, USA.
  • Ely EW; University of Washington, Seattle, Washington, USA.
  • Rice TW; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Casey JD; Geriatric Research, Education, and Clinical Center, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
  • Lindsell CJ; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Gong MN; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Srinivasan V; Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Lewis NM; Montefiore Medical Center, The Bronx, New York, USA.
  • Patel MM; University of Washington, Seattle, Washington, USA.
  • Self WH; CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Influenza Other Respir Viruses ; 16(4): 680-689, 2022 07.
Article in English | MEDLINE | ID: covidwho-1764954
ABSTRACT

BACKGROUND:

We sought to assess whether persistent COVID-19 symptoms beyond 6 months (Long-COVID) among patients with mild COVID-19 is associated with poorer health status, quality of life, and psychological distress.

METHODS:

This was a multicenter prospective cohort study that included adult outpatients with acute COVID-19 from eight sites during 2-week sampling periods from April 1 and July 28, 2020. Participants were contacted 6-11 months after their first positive SARS-CoV-2 to complete a survey, which collected information on the severity of eight COVID-19 symptoms using a 4-point scale ranging from 0 (not present) to 3 (severe) at 1 month before COVID-19 (pre-illness) and at follow-up; the difference for each was calculated as an attributable persistent symptom severity score. A total attributable persistent COVID-19 symptom burden score was calculated by summing the attributable persistent severity scores for all eight symptoms. Outcomes measured at long-term follow-up comprised overall health status (EuroQol visual analogue scale), quality of life (EQ-5D-5L), and psychological distress (Patient Health Questionnaire-4). The association between the total attributable persistent COVID-19 burden score and each outcome was analyzed using multivariable proportional odds regression.

RESULTS:

Of the 2092 outpatients with COVID-19, 436 (21%) responded to the survey. The median (IQR) attributable persistent COVID-19 symptom burden score was 2 (0, 4); higher scores were associated with lower overall health status (aOR 0.63; 95% CI 0.57-0.69), lower quality of life (aOR 0.65; 95%CI 0.59-0.72), and higher psychological distress (aOR 1.40; 95%CI, 1.28-1.54) after adjusting for age, race, ethnicity, education, and income.

CONCLUSIONS:

In participants with mild acute COVID-19, the burden of persistent symptoms was significantly associated with poorer long-term health status, poorer quality of life, and psychological distress.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Psychological Distress / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Humans Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12980

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Psychological Distress / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Humans Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12980