Responsiveness to second and third dose of mRNA COVID-19 vaccination in adolescent and young adult heart transplant recipients.
Pediatr Transplant
; 26(6): e14272, 2022 09.
Article
in English
| MEDLINE | ID: covidwho-1765024
ABSTRACT
BACKGROUND:
Third-dose mRNA COVID-19 vaccine is currently recommended in the United States for SOT recipients based in part on data showing diminished immune response, including Ab production, after a two-dose regimen. Data on vaccine response in adolescent and young adult SOT recipients are limited, including no data reported on third-dose responsiveness.METHODS:
Results of serologic testing in a convenience sample of 28 vaccinated adolescent and young adult HT recipients at a single institution were collected from the medical record and summarized.RESULTS:
At a median of 98.5 days (IQR 59-150) after second dose, 17 (61%) had an Ab response. Among 12 who had serology before and after third-dose vaccination, four of seven who were negative prior to third dose became positive at a median of 34 days (IQR 31-39.5) following third dose. No myocarditis, acute rejection, graft dysfunction, graft loss, or deaths were observed.CONCLUSIONS:
These findings support recommendations for the routine administration of three doses of mRNA vaccines in adolescent and young adult HT recipients and show a potential subpopulation in whom the fourth dose should be contemplated.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Heart Transplantation
/
COVID-19
Type of study:
Experimental Studies
Topics:
Vaccines
Limits:
Adolescent
/
Adult
/
Humans
/
Young adult
Language:
English
Journal:
Pediatr Transplant
Journal subject:
Pediatrics
/
Transplantation
Year:
2022
Document Type:
Article
Affiliation country:
Petr.14272
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