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Enigma of COVID-19: is "multisystem inflammatory syndrome in adults" (MIS-A) predictable?
Serin, Istemi; Sari, Nagehan Didem; Gunaltili, Murat; Karakilic, Ayse; Gulesir, Begum; Kal Kolik, Beyza; Cevik, Gulnihal; Sungurlu, Hilal; Keskin, Melike; Baltik, Muhammed; Cakmak, Onurhan; Cinli, Tahir Alper.
  • Serin I; Department of Hematology, Istanbul Training and Research Hospital, University of Health Sciences, Org.Nafiz GURMAN Cad. Fatih, 34098, Istanbul, Turkey. serinistemi@hotmail.com.
  • Sari ND; Department of Clinical Microbiology and Infectious Diseases, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Gunaltili M; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Karakilic A; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Gulesir B; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Kal Kolik B; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Cevik G; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Sungurlu H; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Keskin M; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Baltik M; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Cakmak O; Department of Internal Medicine, Istanbul Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
  • Cinli TA; Department of Hematology, Istanbul Training and Research Hospital, University of Health Sciences, Org.Nafiz GURMAN Cad. Fatih, 34098, Istanbul, Turkey.
BMC Infect Dis ; 22(1): 300, 2022 Mar 28.
Article in English | MEDLINE | ID: covidwho-1765440
ABSTRACT

BACKGROUND:

Severe inflammation and one or more extrapulmonary organ dysfunctions have been reported and this clinical picture is defined as "multisystem inflammatory syndrome in adults" (MIS-A) in severe coronavirus disease-2019 (COVID-19). We aimed to determine the effect of LDH/lymphocyte ratio (LLR) on the development of MIS-A.

METHODS:

The data of 2333 patients were retrospectively analyzed.

RESULTS:

MIS-A rate was found to be 9.9% and MIS-A related mortality was 35.3%. LRR level above 0.24 was found to predict MIS-A development with 70% sensitivity and 65.2% specificity. The risk of MIS-A development was found to be 3.64 times higher in those with LRR levels above 0.24 compared to those with 0.24 and below. In patients with MIS-A, LRR level above 0.32 predicts mortality with 78% sensitivity and 70% specificity.

CONCLUSIONS:

Early detection of MIS-A with high sensitivity and specificity in a practical ratio is very important in terms new studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Malnutrition / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: S12879-022-07303-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Malnutrition / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: S12879-022-07303-8