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Homocysteine as a marker for predicting disease severity in patients with COVID-19.
Keskin, Adem; U Ustun, Goksenin; Aci, Recai; Duran, Utku.
  • Keskin A; Department of Medicine Biochemistry, Aydin Adnan Menderes University Institute of Health Sciences, Aydin, 09100, Turkey.
  • U Ustun G; Department of Biochemistry, Samsun Training & Research Hospital, Samsun, 55090, Turkey.
  • Aci R; Department of Biochemistry, Samsun Training & Research Hospital, Samsun, 55090, Turkey.
  • Duran U; Department of Veterinary Medicine, Zonguldak Bulent Ecevit University, Çaycuma Food & Agriculture Vocational School, Zonguldak, 67900, Turkey.
Biomark Med ; 16(7): 559-568, 2022 05.
Article in English | MEDLINE | ID: covidwho-1765636
ABSTRACT

Aim:

Our study was designed on the hypothesis that homocysteine levels are a prognostic parameter that can predict the severity of COVID-19 disease. Materials &

methods:

117 COVID-19 patients and 34 non COVID-19 individuals were included in the study. Receiver operating characteristic (ROC) analysis was performed for homocysteine, D-dimer and monocyte/lymphocyte ratio (MLR) levels.

Results:

According to the ROC analysis, in COVID-19 patients group, Area under curve (AUC) values were 0.835 for homocysteine, 0.859 for D-dimer and 0.882 for MLR. According to the ROC analysis, in which homocysteine, MLR and D-dimer parameters were evaluated together, AUC values were 0.951 in the mild disease group, 1000 in severe disease group and 0.967 in COVID-19 patients group.

Conclusion:

It was concluded that homocysteine level is an important parameter in the follow-up of COVID-19 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-0688

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Biomark Med Journal subject: Biochemistry / Medicine Year: 2022 Document Type: Article Affiliation country: Bmm-2021-0688