Endothelial glycocalyx damage in patients with severe COVID-19 on mechanical ventilation - A prospective observational pilot study.
Clin Hemorheol Microcirc
; 81(3): 205-219, 2022.
Article
in English
| MEDLINE | ID: covidwho-1765652
ABSTRACT
BACKGROUND:
Coronavirus disease (COVID-19) associated endotheliopathy and microvascular dysfunction are of concern.OBJECTIVE:
The objective of the present single-center observational pilot study was to compare endothelial glycocalyx (EG) damage and endotheliopathy in patients with severe COVID-19 (COVID-19 group) with patients with bacterial pneumonia with septic shock (non-COVID group).METHODS:
Biomarkers of EG damage (syndecan-1), endothelial cells (EC) damage (thrombomodulin), and activation (P-selectin) were measured in blood on three consecutive days from admission to the intensive care unit (ICU). The sublingual microcirculation was studied by Side-stream Dark Field (SDF) imaging with automatic assessment.RESULTS:
We enrolled 13 patients in the non-COVID group (mean age 70 years, 6 women), and 15 in the COVID-19 group (64 years old, 3 women). The plasma concentrations of syndecan-1 were significantly higher in the COVID-19 group during all three days. Differences regarding other biomarkers were not statistically significant. The assessment of the sublingual microcirculation showed improvement on Day 2 in the COVID-19 group. Plasma levels of C-reactive protein (CRP) were significantly higher on the first two days in the COVID-19 group. Plasma syndecan-1 and CRP were higher in patients suffering from severe COVID-19 pneumonia compared to bacterial pneumonia patients.CONCLUSIONS:
These findings support the role of EG injury in the microvascular dysfunction in COVID-19 patients who require ICU.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Glycocalyx
/
Endothelial Cells
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Clin Hemorheol Microcirc
Journal subject:
Vascular Diseases
/
Hematology
Year:
2022
Document Type:
Article
Affiliation country:
Ch-221401
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