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Prevalence of Chronic Pulmonary Aspergillosis in Patients Suspected of Chest Malignancy.
Rønberg, Rasmus; Davidsen, Jesper Rømhild; Salzer, Helmut J F; Van Braeckel, Eva; Rosenvinge, Flemming Schønning; Laursen, Christian B.
  • Rønberg R; Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
  • Davidsen JR; Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, 5000 Odense, Denmark.
  • Salzer HJF; Odense Patient Data Explorative Network, Odense University Hospital, 5000 Odense, Denmark.
  • Van Braeckel E; Department of Respiratory Medicine, Odense University Hospital, 5000 Odense, Denmark.
  • Rosenvinge FS; South Danish Center for Interstitial Lung Diseases (SCILS), Odense University Hospital, 5000 Odense, Denmark.
  • Laursen CB; Pulmonary Aspergillosis Center Denmark (PACD), Odense University Hospital, 5000 Odense, Denmark.
J Fungi (Basel) ; 8(3)2022 Mar 13.
Article in English | MEDLINE | ID: covidwho-1765755
ABSTRACT
Chronic pulmonary aspergillosis (CPA) is a potentially life-threatening fungal lung infection, and recent research suggests CPA to be more common than previously considered. Although CPA mimics other lung diseases including pulmonary cancer, awareness of this disease entity is still sparse. This study aimed to investigate the prevalence of CPA in a population of patients under suspicion of having lung cancer. We conducted a retrospective cohort study of 1200 patients and manually collected individual health record data from previous cancer examinations, with retrospective CPA status assessment using international criteria. Among 992 included patients, 16 (1.6%) fulfilled diagnostic criteria for CPA retrospectively, of whom 15 were undiscovered at initial lung cancer examination. The prevalence of CPA in this study population was 50 times higher than the reported prevalence of the overall European population. Our findings indicate that CPA is often missed in patients suspected of malignancy in the chest. Therefore, CPA should be kept in mind as a significant differential diagnosis.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jof8030297

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jof8030297