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Positive Role of Delta Neutrophil Index (DNI) as a Prodiagnostic Marker in Cecal Ligation and Puncture (CLP)-Induced Sepsis Murine Model.
Lee, Hyungdon; Lim, Jae Min; Lee, Jongwook; Kim, Soo-Ki; Lee, Taehun.
  • Lee H; Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Sakju-ro 77, Chuncheon-si 24253, Gangwon-do, Korea.
  • Lim JM; Department of Nursing Science, Hallym Polytechnic University, Janghak-gil 48, Dong-myeon, Chuncheon-si 242120, Gangwon-do, Korea.
  • Lee J; Department of Laboratory Medicine, Konyang University Hospital, Gwanjeodon-ro 158, Seo-gu, Daejeon-si 35365, Korea.
  • Kim SK; Department of Microbiology, Wonju College of Medicine, Yonsei University, Ilsan-ro 20, Wonju-si 26426, Gangwon-do, Korea.
  • Lee T; Department of Emergency Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Sakju-ro 77, Chuncheon-si 24253, Gangwon-do, Korea.
Medicina (Kaunas) ; 58(3)2022 Mar 02.
Article in English | MEDLINE | ID: covidwho-1765786
ABSTRACT
Sepsis is an emergent infectious disease and a leading cause of death despite immediate intervention. While Delta neutrophil index (DNI) and myeloperoxidase (MPO) are known as a prodiagnostic marker of sepsis, the preclinical evidence of the best marker of sepsis is unclear. For this, using a well-designed cecal ligation and puncture (CLP)-induced sepsis mouse model, we comparatively measured the level and cost-effectiveness of sepsis biomarkers such as DNI, myeloperoxidase (MPO), procalcitonin (PCT), and tumor necrosis factor-alpha (TNF-α). First, we found that the optimal time point for early detection is at 6 h, 24 h post-CLP. Strikingly, the peak level and fold change of DNI was revealed at 24 h, further showing the best fold change as compared with other biomarker levels. Given the fold change at 6, 24 h, PCT was next to DNI. Third, a cost-effectiveness survey showed that DNI was the best, with PCT next. Further, DNI level was moderate positively associated with PCT (ρ = 0.697, p = 0.012) and TNF-α (ρ = 0.599, p = 0.040). Collectively, these data indicate that DNI in CLP-induced sepsis mice is as effective as the existent inflammatory biomarkers such as MPO, PCT and TNF-α to predict the prognosis of sepsis. This might have clinically important implications that DNI is cost effective, thus quickly and rationally applying to diverse types of imminent sepsis regardless of species. This might be the first report on the validity of DNI in preclinical CLP-induced murine sepsis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / Neutrophils Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal subject: Medicine Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / Neutrophils Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal subject: Medicine Year: 2022 Document Type: Article