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Prevalence of SARS CoV-2 spike antibody in post COVID or post vaccinated individuals
Indian Journal of Clinical Biochemistry ; 36(SUPPL 1):S149, 2021.
Article in English | EMBASE | ID: covidwho-1767667
ABSTRACT
Background &

Objective:

SARS-CoV-2 pandemic is causing high morbidity and mortality burden worldwide with unprecedented strain on health care systems. Data on the prevalence of the SARS-CoV-2 antibody is expanding with growing research. The initial data on antibodies was available for nucleocapsid target proteins however with advancing research and development of vaccines against the Spike RBD domain of the virus, antibody assays are being focussed to the Spike RBD proteins. The current study aims to understand the prevalence of Anti-Spike SARS cov2 antibodies.

Method:

A commercially available assay targeting the SPIKE RBD domain of the virus using a chemiluminescent microparticle immunoassay was used for the qualitative and quantitative determination of IgG antibodies to SARS-CoV-2 in a total of 260 individuals.

Results:

A total of 260 individuals were screened which included 147 males and 113 females with a mean age of 51+16 years. A positive seroprevalence was observed in 85.3% (222/260) individuals. Vaccination details were available for 225 individuals wherein 194 were seropositive. Around 12% did not show presence of antibodies (26/211) even after 21 days of vaccination. A few non-vaccinated individuals were seropositive due to prior history of Covid infection. However, 7 individuals with past history of Covid infection and 2 post vaccination were negative for antibodies.

Conclusion:

Serological testing plays a vital role in understanding and ultimately combating viral outbreaks and can help identifying individuals with an adaptive immune response to SARSCoV-2, indicating recent or prior infection. A high prevalence of positive spike antibodies is observed in most individuals.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Topics: Long Covid / Vaccines Language: English Journal: Indian Journal of Clinical Biochemistry Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Topics: Long Covid / Vaccines Language: English Journal: Indian Journal of Clinical Biochemistry Year: 2021 Document Type: Article