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Genetic and non-genetic risk factors associated with atrial fibrillation.
Young, Lindsay J; Antwi-Boasiako, Steve; Ferrall, Joel; Wold, Loren E; Mohler, Peter J; El Refaey, Mona.
  • Young LJ; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
  • Antwi-Boasiako S; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
  • Ferrall J; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.
  • Wold LE; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; College of Nursing, The Ohio State University, Columbus, OH, U
  • Mohler PJ; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Department of Internal Medicine, Division of Cardiovascular Me
  • El Refaey M; The Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA; Department of Surgery, Division of Cardiac Surgery, The Ohio State University, Columbus, OH, USA. Electronic address: Mona.elrefaey@osumc.edu.
Life Sci ; 299: 120529, 2022 Jun 15.
Article in English | MEDLINE | ID: covidwho-1768390
ABSTRACT
Atrial fibrillation (AF) is the most common arrhythmic disorder and its prevalence in the United States is projected to increase to more than twelve million cases in 2030. AF increases the risk of other forms of cardiovascular disease, including stroke. As the incidence of atrial fibrillation increases dramatically with age, it is paramount to elucidate risk factors underlying AF pathogenesis. Here, we review tissue and cellular pathways underlying AF, as well as critical components that impact AF susceptibility including genetic and environmental risk factors. Finally, we provide the latest information on potential links between SARS-CoV-2 and human AF. Improved understanding of mechanistic pathways holds promise in preventative care and early diagnostics, and also introduces novel targeted forms of therapy that might attenuate AF progression and maintenance.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atrial Fibrillation / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Life Sci Year: 2022 Document Type: Article Affiliation country: J.lfs.2022.120529

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Atrial Fibrillation / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: North America Language: English Journal: Life Sci Year: 2022 Document Type: Article Affiliation country: J.lfs.2022.120529