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COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea.
George, Carolin Elizabeth; Scheuch, Gerhard; Seifart, Ulf; Inbaraj, Leeberk Raja; Chandrasingh, Sindhulina; Nair, Indu K; Hickey, Anthony J; Barer, Michael R; Fletcher, Eve; Field, Rachel D; Salzman, Jonathan; Moelis, Nathan; Ausiello, Dennis; Edwards, David A.
  • George CE; Bangalore Baptist Hospital, Bangalore, India. Carolinelizabethj@gmail.com.
  • Scheuch G; GS BIO-INHALATION GmbH, Germunden, Germany. Gerhard.scheuch@bio-inhalation.com.
  • Seifart U; Klinik Sonnenblick, Marburg, Germany.
  • Inbaraj LR; Bangalore Baptist Hospital, Bangalore, India.
  • Chandrasingh S; Bangalore Baptist Hospital, Bangalore, India.
  • Nair IK; Bangalore Baptist Hospital, Bangalore, India.
  • Hickey AJ; RTI International, Research Triangle Park, NC, USA.
  • Barer MR; Respiratory Sciences, University of Leicester, Leicester, UK.
  • Fletcher E; Respiratory Sciences, University of Leicester, Leicester, UK.
  • Field RD; School of Engineering & Applied Sciences, Columbia University, New York, NY, USA.
  • Salzman J; Sensory Cloud, 650 East Kendall St, Cambridge, MA, USA.
  • Moelis N; School of Bioengineering, Northeastern University, Huntington Avenue, Boston, MA, USA.
  • Ausiello D; Massachusetts General Hospital, Boston, MA, USA.
  • Edwards DA; Sensory Cloud, 650 East Kendall St, Cambridge, MA, USA. dedwards@seas.harvard.edu.
Sci Rep ; 12(1): 4599, 2022 03 29.
Article in English | MEDLINE | ID: covidwho-1931433
ABSTRACT
Dehydration of the upper airways increases risks of respiratory diseases from COVID-19 to asthma and COPD. We find in human volunteer studies involving 464 human subjects in Germany, the US, and India that respiratory droplet generation increases by up to 4 orders of magnitude in dehydration-associated states of advanced age (n = 357), elevated BMI-age (n = 148), strenuous exercise (n = 20) and SARS-CoV-2 infection (n = 87), and falls with hydration of the nose, larynx and trachea by calcium-rich hypertonic salts. We also find in a protocol of exercise-induced airway dehydration that hydration of the airways by calcium-rich salts increases oxygenation relative to a non-treatment control (P < 0.05). In a random control study of COVID-19 positive subjects (n = 40), thrice-a-day delivery of the calcium-rich hypertonic salts (active) suppressed respiratory droplet generation by 51% ± 11% and increased oxygen saturation over three days of treatment by 48.08% ± 9.61% (P < 0.001), while no changes were observed in the nasal-saline control group. Self-reported symptoms significantly declined in the active group and did not decline in the control group. Hydration of the upper airways appears promising as a non-drug approach for reducing risks of respiratory diseases such as COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Larynx Type of study: Diagnostic study / Clinical Practice Guide / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-08609-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Larynx Type of study: Diagnostic study / Clinical Practice Guide / Observational study / Randomized controlled trials Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-08609-y