Human liver organoid derived intra-hepatic bile duct cells support SARS-CoV-2 infection and replication.
Sci Rep
; 12(1): 5375, 2022 03 30.
Article
in English
| MEDLINE | ID: covidwho-1768850
ABSTRACT
Although the main route of infection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the respiratory tract, liver injury is also commonly seen in many patients, as evidenced by deranged parenchymal liver enzymes. Furthermore, the severity of liver damage has been shown to correlate with higher mortality. Overall, the mechanism behind the liver injury remains unclear. We showed in this study that intra-hepatic bile duct cells could be grown using a human liver organoid platform. The cholangiocytes were not only susceptible to SARS-CoV-2 infection, they also supported efficient viral replication. We also showed that SARS-CoV-2 replication was much higher than SARS-CoV. Our findings suggested direct cytopathic viral damage being a mechanism for SARS-CoV-2 liver injury.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bile Ducts, Extrahepatic
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Sci Rep
Year:
2022
Document Type:
Article
Affiliation country:
S41598-022-09306-6
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