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Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19).
Alhazzani, Waleed; Møller, Morten Hylander; Arabi, Yaseen M; Loeb, Mark; Gong, Michelle Ng; Fan, Eddy; Oczkowski, Simon; Levy, Mitchell M; Derde, Lennie; Dzierba, Amy; Du, Bin; Aboodi, Michael; Wunsch, Hannah; Cecconi, Maurizio; Koh, Younsuck; Chertow, Daniel S; Maitland, Kathryn; Alshamsi, Fayez; Belley-Cote, Emilie; Greco, Massimiliano; Laundy, Matthew; Morgan, Jill S; Kesecioglu, Jozef; McGeer, Allison; Mermel, Leonard; Mammen, Manoj J; Alexander, Paul E; Arrington, Amy; Centofanti, John E; Citerio, Giuseppe; Baw, Bandar; Memish, Ziad A; Hammond, Naomi; Hayden, Frederick G; Evans, Laura; Rhodes, Andrew.
  • Alhazzani W; Department of Medicine, McMaster University, Hamilton, Canada.
  • Møller MH; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
  • Arabi YM; Department of Intensive Care, Copenhagen University Hospital Rigshospitalet, 4131, Copenhagen, Denmark.
  • Loeb M; Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI), Copenhagen, Denmark.
  • Gong MN; Intensive Care Department, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia.
  • Fan E; Department of Medicine, McMaster University, Hamilton, Canada.
  • Oczkowski S; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
  • Levy MM; Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA.
  • Derde L; Interdepartmental Division of Critical Care Medicine, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
  • Dzierba A; Department of Medicine, McMaster University, Hamilton, Canada.
  • Du B; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada.
  • Aboodi M; Warren Alpert School of Medicine, Brown University, Providence, RI, USA.
  • Wunsch H; Rhode Island Hospital, Providence, RI, USA.
  • Cecconi M; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Koh Y; Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands.
  • Chertow DS; Department of Pharmacy, NewYork-Presbyterian Hospital, Columbia University Irving Medical Center, New York, NY, USA.
  • Maitland K; Medical ICU, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730, China.
  • Alshamsi F; Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Medicine, Montefiore Healthcare System/Albert Einstein College of Medicine, Bronx, NY, USA.
  • Belley-Cote E; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • Greco M; Department of Anesthesia and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
  • Laundy M; Department of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  • Morgan JS; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Kesecioglu J; Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • McGeer A; Critical Care Medicine Department, National Institutes of Health Clinical Center and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Baltimore, USA.
  • Mermel L; Faculty of Medicine, Imperial College, London, UK.
  • Mammen MJ; Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates.
  • Alexander PE; Department of Medicine, McMaster University, Hamilton, Canada.
  • Arrington A; Population Health Research Institute, Hamilton, Canada.
  • Centofanti JE; Department of Anesthesia and Intensive Care, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
  • Citerio G; Department of Biomedical Science, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Baw B; Microbiology and Infection Control, St George's University Hospitals NHS Foundation Trust & St George's University of London, London, UK.
  • Memish ZA; Emory University Hospital, Atlanta, USA.
  • Hammond N; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Hayden FG; Division of Infectious Diseases, University of Toronto, Toronto, Canada.
  • Evans L; Warren Alpert School of Medicine, Brown University, Providence, RI, USA.
  • Rhodes A; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, USA.
Intensive Care Med ; 46(5): 854-887, 2020 05.
Article in English | MEDLINE | ID: covidwho-17690
Semantic information from SemMedBD (by NLM)
1. Critical Illness PROCESS_OF Adult
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Adult
2. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
3. intensive care unit LOCATION_OF Administration occupational activities
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Administration occupational activities
4. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Infectious disease prevention / control TREATS COVID-19
Subject
Infectious disease prevention / control
Predicate
TREATS
Object
COVID-19
7. Critical Illness PROCESS_OF Adult
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Adult
8. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
9. intensive care unit LOCATION_OF Administration occupational activities
Subject
intensive care unit
Predicate
LOCATION_OF
Object
Administration occupational activities
10. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Infectious disease prevention / control TREATS COVID-19
Subject
Infectious disease prevention / control
Predicate
TREATS
Object
COVID-19
ABSTRACT

BACKGROUND:

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

METHODS:

We formed a panel of 36 experts from 12 countries. All panel members completed the World Health Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.

RESULTS:

The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy.

CONCLUSION:

The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new recommendations in further releases of these guidelines.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Sepsis / Critical Care / Intensive Care Units Type of study: Diagnostic study / Etiology study / Clinical Practice Guide / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Intensive Care Med Year: 2020 Document Type: Article Affiliation country: S00134-020-06022-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Sepsis / Critical Care / Intensive Care Units Type of study: Diagnostic study / Etiology study / Clinical Practice Guide / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Intensive Care Med Year: 2020 Document Type: Article Affiliation country: S00134-020-06022-5