T cell responses in respiratory viral infections and chronic obstructive pulmonary disease.
Chin Med J (Engl)
; 134(13): 1522-1534, 2021 Mar 01.
Article
in English
| MEDLINE | ID: covidwho-1769417
ABSTRACT
ABSTRACT Respiratory viruses are major human pathogens that cause approximately 200 million pneumonia cases annually and induce various comorbidities with chronic obstructive pulmonary disease (COPD), resulting in significant health concerns and economic burdens. Clinical manifestations in respiratory viral infections and inflammations vary from asymptomatic, mild, to severe, depending on host immune cell responses to pathogens and interactions with airway epithelia. We critically review the activation, effector, and regulation of T cells in respiratory virus infections and chronic inflammations associated with COPD. Crosstalk among T cells, innate immune cells, and airway epithelial cells is discussed as essential parts of pathogenesis and protection in viral infections and COPD. We emphasize the specificity of peptide antigens and the functional heterogeneity of conventional CD4+ and CD8+ T cells to shed some light on potential cellular and molecular candidates for the future development of therapeutics and intervention against respiratory viral infections and inflammations.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia
/
Respiratory Tract Infections
/
Viruses
/
Virus Diseases
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Chin Med J (Engl)
Year:
2021
Document Type:
Article
Affiliation country:
CM9.0000000000001388
Similar
MEDLINE
...
LILACS
LIS