Your browser doesn't support javascript.
AVP-eGFP was significantly upregulated by hypovolemia in the parvocellular division of the paraventricular nucleus in the transgenic rats.
Sanada, Kenya; Ueno, Hiromichi; Miyamoto, Tetsu; Baba, Kazuhiko; Tanaka, Kentaro; Nishimura, Haruki; Nishimura, Kazuaki; Sonoda, Satomi; Yoshimura, Mitsuhiro; Maruyama, Takashi; Onaka, Tatsushi; Otsuji, Yutaka; Kataoka, Masaharu; Ueta, Yoichi.
  • Sanada K; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Ueno H; Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Miyamoto T; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Baba K; Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Tanaka K; Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Nishimura H; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Nishimura K; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Sonoda S; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Yoshimura M; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Maruyama T; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Onaka T; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Otsuji Y; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Kataoka M; Division of Brain and Neurophysiology, Department of Physiology, Jichi Medical University, Shimotsuke, Japan.
  • Ueta Y; Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Am J Physiol Regul Integr Comp Physiol ; 322(3): R161-R169, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1770007
ABSTRACT
Arginine vasopressin (AVP) is produced in the paraventricular (PVN) and supraoptic nuclei (SON). Peripheral AVP, which is secreted from the posterior pituitary, is produced in the magnocellular division of the PVN (mPVN) and SON. In addition, AVP is produced in the parvocellular division of the PVN (pPVN), where corticotrophin-releasing factor (CRF) is synthesized. These peptides synergistically modulate the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies have revealed that the HPA axis was activated by hypovolemia. However, the detailed dynamics of AVP in the pPVN under hypovolemic state has not been elucidated. Here, we evaluated the effects of hypovolemia and hyperosmolality on the hypothalamus, using AVP-enhanced green fluorescent protein (eGFP) transgenic rats. Polyethylene glycol (PEG) or 3% hypertonic saline (HTN) was intraperitoneally administered to develop hypovolemia or hyperosmolality. AVP-eGFP intensity was robustly upregulated at 3 and 6 h after intraperitoneal administration of PEG or HTN in the mPVN. While in the pPVN, eGFP intensity was significantly increased at 6 h after intraperitoneal administration of PEG with significant induction of Fos-immunoreactive (-ir) neurons. Consistently, eGFP mRNA, AVP hnRNA, and CRF mRNA in the pPVN and plasma AVP and corticosterone were significantly increased at 6 h after intraperitoneal administration of PEG. The results suggest that AVP and CRF syntheses in the pPVN were activated by hypovolemia, resulting in the activation of the HPA axis.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Paraventricular Hypothalamic Nucleus / Arginine Vasopressin / Hypovolemia / Green Fluorescent Proteins / Hypothalamo-Hypophyseal System Type of study: Experimental Studies / Randomized controlled trials Limits: Animals Language: English Journal: Am J Physiol Regul Integr Comp Physiol Journal subject: Physiology Year: 2022 Document Type: Article Affiliation country: AJPREGU.00107.2021

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Paraventricular Hypothalamic Nucleus / Arginine Vasopressin / Hypovolemia / Green Fluorescent Proteins / Hypothalamo-Hypophyseal System Type of study: Experimental Studies / Randomized controlled trials Limits: Animals Language: English Journal: Am J Physiol Regul Integr Comp Physiol Journal subject: Physiology Year: 2022 Document Type: Article Affiliation country: AJPREGU.00107.2021