Your browser doesn't support javascript.
Genetic diversity and epidemiology of human rhinovirus among children with severe acute respiratory tract infection in Guangzhou, China.
Li, Wanwei; Yu, Bo; Zhou, Jijian; Wang, Yanlan; Xue, Bao; Pan, Jialong; Ran, Yanhong; Yang, Xiaoping; Wang, Xiaoping; Yang, Fang; Li, Hongjian.
  • Li W; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Yu B; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Zhou J; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Wang Y; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Xue B; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Pan J; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
  • Ran Y; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Yang X; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China.
  • Wang X; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
  • Yang F; First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China. tyf@jnu.edu.cn.
  • Li H; The Key Laboratory for Virology of Guangzhou, Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China. tlihj@jnu.edu.cn.
Virol J ; 18(1): 174, 2021 08 23.
Article in English | MEDLINE | ID: covidwho-1770553
ABSTRACT

BACKGROUND:

Human rhinovirus (HRV) is one of the major viruses of acute respiratory tract disease among infants and young children. This work aimed to understand the epidemiological and phylogenetic features of HRV in Guangzhou, China. In addition, the clinical characteristics of hospitalized children infected with different subtype of HRV was investigated.

METHODS:

Hospitalized children aged < 14 years old with acute respiratory tract infections were enrolled from August 2018 to December 2019. HRV was screened for by a real-time reverse-transcription PCR targeting the viral 5'UTR.

RESULTS:

HRV was detected in 6.41% of the 655 specimens. HRV infection was frequently observed in children under 2 years old (57.13%). HRV-A and HRV-C were detected in 18 (45%) and 22 (55%) specimens. All 40 HRV strains detected were classified into 29 genotypes. The molecular evolutionary rate of HRV-C was estimated to be 3.34 × 10-3 substitutions/site/year and was faster than HRV-A (7.79 × 10-4 substitutions/site/year). Children who experienced rhinorrhoea were more common in the HRV-C infection patients than HRV-A. The viral load was higher in HRV-C detection group than HRV-A detection group (p = 0.0148). The median peak symptom score was higher in patients with HRV-C infection as compared to HRV-A (p = 0.0543), even though the difference did not significance.

CONCLUSION:

This study revealed the molecular epidemiological characteristics of HRV in patients with respiratory infections in southern China. Children infected with HRV-C caused more severe disease characteristics than HRV-A, which might be connected with higher viral load in patients infected with HRV-C. These findings will provide valuable information for the pathogenic mechanism and treatment of HRV infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Rhinovirus / Picornaviridae Infections Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Humans / Infant Country/Region as subject: Asia Language: English Journal: Virol J Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12985-021-01645-6

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Rhinovirus / Picornaviridae Infections Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Humans / Infant Country/Region as subject: Asia Language: English Journal: Virol J Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: S12985-021-01645-6