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Immunohistochemical Expression of VDR in Myocardium: Postmortem Evaluation of COVID-19 Patients.
Kriventsov, Maxim A; Yermola, Yulianna A; Davydova, Alexandra A; Beketov, Alexey A; Makalish, Tatyana P; Zyablitskaya, Evgeniya Yu; Geraschenko, Alina V; Kubyshkin, Anatoly V; Galyshevskaya, Anna A; Zausalina, Anastasia I.
  • Kriventsov MA; Department of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Yermola YA; Department of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Davydova AA; Department of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Beketov AA; Department of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Makalish TP; Central Research Laboratory, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Zyablitskaya EY; Central Research Laboratory, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Geraschenko AV; Central Research Laboratory, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Kubyshkin AV; Department of Pathophysiology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Galyshevskaya AA; Department of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
  • Zausalina AI; Department of Pathomorphology, Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, Russia.
J Histochem Cytochem ; 70(5): 391-399, 2022 05.
Article in English | MEDLINE | ID: covidwho-1770632
ABSTRACT
Morphological data on heart damage and its mechanisms due to extremely severe course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are limited, as well as data on the correlation of damage and expression of vitamin D receptors (VDRs). In this study, we analyzed a series of myocardial samples obtained during postmortem autopsy of 48 critically ill patients with COVID-19 who died with SARS-CoV-2-associated pneumonia. The purpose of the study was to evaluate immunohistochemical VDR expression in the myocardium. The results showed the only minimal or no immunohistochemical expression of VDR in the nuclei of cardiomyocytes in most cases, along with the persisted strong expression in lymphoid cells. To the best of our knowledge, it is the first study and data provided were regarding myocardial VDR expression in COVID-19 patients. The results are of interest in terms of further study of the effects of ligand-associated VDR activation on the cardiovascular system.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: J Histochem Cytochem Journal subject: Histocytochemistry Year: 2022 Document Type: Article Affiliation country: 00221554221089916

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: J Histochem Cytochem Journal subject: Histocytochemistry Year: 2022 Document Type: Article Affiliation country: 00221554221089916