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Clinical Features and Laboratory Findings of COVID-19 in Children: A Tertiary Center Experience
Çocuklarda COVID-19'un Klinik Özellikleri ve Laboratuvar Bulguları: &Uuml ; çüncü Basamak Merkez Deneyimi.; 33(1):1-8, 2022.
Article in English | Academic Search Complete | ID: covidwho-1771855
ABSTRACT

Objective:

Despite increasing data on Coronavirus Disease 2019 (COVID-19) in adults, the data in pediatric patients are still limited. The aim of our study is to evaluate the clinical features and laboratory findings of our confirmed pediatric COVID-19 cases.

Methods:

This retrospective descriptive study was conducted in one of the largest COVID-19 treatment centers in Ístanbul, Turkey. Four hundred and fifty-six cases confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) were included in the study. One hundred inpatients and 356 outpatients were treated. Patients were classified according to the disease severity as asymptomatic, mild, moderate and severe.

Results:

The number of asymptomatic, mild, moderate or severe cases were 199 (43.6%), 194 (42.5%), 33 (7.2%) and 30 (6.6%) respectively. Most of the hospitalized patients younger than 5 years old had the mild disease (67.7%), whereas most of the patients over 15 years of age had severe disease (54.2%). Lymphopenia and high ferritin levels at admission were more common in severe cases (p<0.05). Also, multiple regression analysis revealed that high ferritin and D-dimer levels were found to prolong hospital stay (p=0.000;R2=0.404).

Conclusion:

Age, lymphocyte count, ferritin and D-dimer levels can be used to estimate the disease severity for COVID-19 infection in children. (English) [ FROM AUTHOR] Amaç Erişkinlerde Coronavirus Hastalığı 2019 (COVID-19) hakkında artan verilere rağmen, pediatrik hastalardaki veriler hala sınırlıdır. Çalışmamızın amacı, doğrulanmış pediatrik COVID-19 olgularımızın klinik özelliklerini ve laboratuvar bulgularını değerlendirmektir. Gereç ve Yöntem Bu geriye dönük çalışma, Türkiye'deki en büyük COVID-19 tedavi merkezlerinden birinde yapıldı. Çalışmaya ters transkriptaz polimeraz zincir reaksiyonu (RT-PCR) kullanılarak doğrulanan 456 olgu dahil edildi.Yüz hasta yatarak, 356 hasta ayakta tedavi edildi. Hastalar hastalık şiddetine göre asemptomatik, hafif, orta ve şiddetli olarak sınıflandırıldı. Bulgular Asemptomatik, hafif, orta ve ağır vaka sayısı sırasıyla 199 (%43.6), 194 (%42.5), 33 (%7.2) ve 30 (%6.6) idi. Hastanede yatan beş yaş altı hastaların çoğu hafif (%67.7) iken, 15 yaş üstü hastaların çoğu ağır hastalığa (%54.2) sahipti. Başvuru anında lenfopeni ve yüksek ferritin düzeyleri ağır olgularda daha yaygındı (p<0.05). Ayrıca çoklu regresyon analizi, yüksek ferritin ve D-dimer düzeylerinin hastanede yatış süresini artırdığını ortaya koydu (p=0.000;R2=0.404). Sonuç Çocuklarda COVID-19 enfeksiyonu için hastalık şiddetini tahmin etmek için yaş, lenfosit sayısı, ferritin ve D-dimer seviyeleri kullanılabilir. (Turkish) [ FROM AUTHOR] Copyright of Southern Clinics of Istanbul Eurasia is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
Keywords

Full text: Available Collection: Databases of international organizations Database: Academic Search Complete Type of study: Prognostic study Language: English Journal: Çocuklarda COVID-19'un Klinik Özellikleri ve Laboratuvar Bulguları: &Uuml;çüncü Basamak Merkez Deneyimi. Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Academic Search Complete Type of study: Prognostic study Language: English Journal: Çocuklarda COVID-19'un Klinik Özellikleri ve Laboratuvar Bulguları: &Uuml;çüncü Basamak Merkez Deneyimi. Year: 2022 Document Type: Article