Injection Effect of Anti-CD3 Monoclonal Antibody on Primo Vessel in Lymph Vessel of Rabbit with Lipopolysaccharide-Induced Inflammation.
J Acupunct Meridian Stud ; 15(1): 37-42, 2022 Feb 28.
Article in English | MEDLINE | ID: covidwho-1772266
Background:The primo vascular system can be viewed as a circulatory system that plays a therapeutic function in regenerating the body tissue. The anti-CD3 monoclonal antibody was used as an immunotherapeutic agent to treat the novel coronavirus infection (COVID-19).
Objectives:In this study, we observed the effect of injecting lymph nodes with Foralumab, an anti- human CD3 epsilon therapeutic monoclonal antibody, on primo vessels.
Methods:The structure and atomic stoichiometry of the antibody were determined by transmission electron microscopy and energy dispersive spectroscopy. Alcian blue dying solution was injected into the lymph nodes of the abdominal vena cava of rabbits, and the solution further flowed into the lymph vessels.
Results:A primo vessel with primo nodes stained with Alcian blue was clearly visible in the lymph vessel. By injecting Foralumab into lymph nodes of rabbits with lipopolysaccharide-induced inflammation, the floating primo vessel in the lymph vessel appeared thicker and was distinctly visible.
Conclusion:The observation of the primo vessel post-treated with Foralumab in the inflamed lymphatic system suggests the possibility of a functional role of the primo vascular circulatory system in pathophysiological conditions.
Full text: Available Collection: International databases Database: MEDLINE Main subject: Meridians / Lymphatic Vessels / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Traditional medicine Limits: Animals Language: English Journal: J Acupunct Meridian Stud Journal subject: Complementary Therapies Year: 2022 Document Type: Article