Levels of Electrolytes, Troponin and association of O2 saturation with D-Dimer and Ferritin in hospitalized COVID-19 patients

ABSTRACT

A cluster of atypical pneumonia cases were reported in Wuhan china at the end of 2019. The disease was subsequently named covid-19. Later on it spread across the globe and WHO declared it as greatest pandemic of 21st century. Previous studies show that majority of the patients have hyponatremia, hypokalemia and hypochloremia. Recent study also suggests that the value of D-Dimer, ferritin and troponin I increasewhile O2 saturation drops in covid-19 patients.A cross sectional observational study was carried out in Peshawar Pakistan. A total of 195 patients above 18 years of age, confirmed through real time PCR were studied. Most of the patients have normal levels of electrolytes (Reference range of sodium 135-150mmol/L, potassium 3.5-5.1mmol/L, chloride 96-112mmol/L)while the patients with abnormal levels includedhyponatremic patients (having sodium level less than 135mmol/L), hyperkalemic patients (having potassium level higher than 5.1mmol/L) and hypochloremic patients (having chloride level less than 96mmol/L). The abnormal level of electrolytes is due to renal abnormalities. An association of O2 saturation exists with ferritin and D-Dimer. The level ofTroponin I raisestwofold in COVID-19 patients, which is an important circulatory biomarker associated with myocardial injury.