Drug-drug interactions between COVID-19 treatments and antidepressants, mood stabilizers/anticonvulsants, and benzodiazepines: Integrated evidence from 3 databases
Pharmacopsychiatry
; 55(1):40-47, 2022.
Article
in English
| APA PsycInfo | ID: covidwho-1772432
ABSTRACT
Introduction:
The SARS-CoV-2 pandemic with psychiatric comorbidities leads to a scenario in which the use of psychotropic drugs may be required. This requires the support of evidence-based medicine to take into account possible interactions between antidepressants, mood stabilizers, benzodiazepines, and coronavirus infection treatments.Methods:
Three databases were consulted (a) Lexicomp Drug Interactions, (b) Micromedex Solutions Drugs Interactions, (c) Liverpool Drug Interaction Group for COVID-19 therapies. The CredibleMeds QTDrugs List was also queried. Hydroxychloroquine, chloroquine, azithromycin, lopinavir-ritonavir, remdesivir, favipiravir, tocilizumab, baricitinib, anakinra, and dexamethasone - drugs used for SARS-CoV-2-were analyzed, and consensus recommendations are made.Results:
The potential interactions of agomelatine, desvenlafaxine, duloxetine, milnacipran, and vortioxetine with COVID-19 treatments shall be considered less risky. Antidepressant interactions with hydroxychloroquine, chloroquine, and azithromycin enhance the risk of QT prolongation, and ECG monitoring is advised for most antidepressants. Antidepressants with lopinavir/ ritonavir involve multiple CYP enzyme interactions (except with milnacipran). Gabapentin, oxcarbazepine, pregabalin, topiramate, and zonisamide are safe treatment options that have no significant interactions with COVID-19 treatments. Lithium is contraindicated with hydroxychloroquine, chloroquine, and azithromycin. Precaution should be taken in using valproic acid with lopinavir-ritonavir. The use of benzodiazepines does not present a risk of drug interaction with COVID-19 treatments, except lopinavir/ritonavir.Conclusions:
Clinicians prescribing antidepressants, mood stabilizers/anticonvulsants, and benzodiazepines, should be aware of the probable risk of drug-drug interaction with COVID- 19 medications and may benefit from heeding these recommendations for use to ensure patient safety. (PsycInfo Database Record (c) 2022 APA, all rights reserved)
antidepressants, anticonvulsants, lithium, benzodiazepines, SARS-CoV-2 infection, coronavirus disease 2019, mental health; *Antidepressant Drugs; *Benzodiazepines; *Drug Interactions; *Drug Therapy; *covid-19; Emotional States; Infectious Disorders; Lithium; Physical & Somatoform & Psychogenic Disorders [3290]; Medical Treatment of Physical Illness [3363]; Human
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Collection:
Databases of international organizations
Database:
APA PsycInfo
Language:
English
Journal:
Pharmacopsychiatry
Year:
2022
Document Type:
Article
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