Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses.
Cell Stress Chaperones
; 27(3): 189-195, 2022 05.
Article
in English
| MEDLINE | ID: covidwho-1773013
ABSTRACT
Free radical release due to oxidative stress is gaining importance in the field of viral pathogenesis. Recent studies suggest the involvement of oxidative stress and ROS levels in regulating disease virulence during RNA virus infection. Most of the RNA virus infections lead to vascular dysfunction and disease severity. However, the biology of free radicals in maintaining vascular endothelium integrity is not completely understood. In the present review, we discuss some of the common features in positive-strand RNA virus infections such as dengue and SARS-CoV-2 and suggest that anti-oxidant therapy could pave the way to develop therapeutic strategies in combating emerging and re-emerging RNA viruses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cell Stress Chaperones
Year:
2022
Document Type:
Article
Affiliation country:
S12192-022-01269-x
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