Glucose dysregulation and its association with COVID-19 mortality and hospital length of stay.
Diabetes Metab Syndr
; 16(3): 102439, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1773263
ABSTRACT
BACKGROUND AND AIMS:
We investigate the impact of blood glucose on mortality and hospital length of stay (HLOS) among COVID-19 patients.METHODS:
Retrospective study of 456 patients with confirmed COVID-19 and glycemic dysregulation in the New York City area.RESULTS:
We found that impaired glucose adjusted for other organs systems involved (OR1.87; 95% CI1.36-2.57, p < 0.001), increased glucose nadir (OR34.28; 95% CI3.97-296.05, p < 0.01) and abnormal blood glucose levels at discharge (OR5.07; 95% CI2.31-11.14, p < 0.001) were each significantly associated with increased odds for mortality. New or higher from baseline insulin requirement during hospitalization (OR0.34; 95% CI0.15-0.78; p < 0.05) was significantly associated with decreased odds for mortality. Increased glucose peak (B = 0.001, SE=<0.001, p < 0.001), new or higher from baseline insulin requirement during hospitalization (B = 0.11, SE = 0.03, p < 0.001), and increased days to dysglycemia (B = 0.15, SE = 0.04, p < 0.001) were each significantly associated with increased HLOS. Increased glucose nadir (B = -0.67, SE = 0.07, p < 0.001), insulin intravenous drip (B = -0.10, SE = 0.05, p < 0.05), and increased proportion days endocrine system involved (B = -0.25, SE = 0.06, p < 0.001) were each significantly associated with decreased HLOS.CONCLUSION:
Glucose dysregulation adversely affects mortality and HLOS in COVID-19. These data can help clinicians to guide patient treatment and management in COVID-19 patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Diabetes Metab Syndr
Year:
2022
Document Type:
Article
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