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Humoral immune response to Comirnaty (BNT162b2) SARS-Cov2 mRNA vaccine in Thalassemia Major patients.
Anastasi, Emanuela; Marziali, Marco; Preziosi, Adele; Berardelli, Elena; Losardo, Anna Annunziata; Ribersani, Michela; Pugliese, Pellegrina; Farina, Antonella; Mancini, Patrizia; Angeloni, Antonio.
  • Anastasi E; Department of Experimental Medicine, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy. Electronic address: emanuela.anastasi@uniroma1.it.
  • Marziali M; Immunohematology and Transfusion Medicine Unit, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Preziosi A; Department of Experimental Medicine, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Berardelli E; Department of Experimental Medicine, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Losardo AA; Immunohematology and Transfusion Medicine Unit, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Ribersani M; Hematology, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Pugliese P; Immunohematology and Transfusion Medicine Unit, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Farina A; Department of Experimental Medicine, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Mancini P; Department of Experimental Medicine, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
  • Angeloni A; Department of Experimental Medicine, Policlinico Umberto 1, Sapienza Università di Roma, Roma, Italy.
Microbes Infect ; 24(6-7): 104976, 2022 09.
Article in English | MEDLINE | ID: covidwho-1773645
ABSTRACT
One of the most urgent needs worldwide is to vaccinate against SARS-CoV-2 as many people as possible. We evaluated humoral response to Comirnaty vaccine in Thalassemia Major patients (TM). We measured SARS-CoV-2-specific antibodies against Spike protein in 57 TM patients and 58 healthy blood donors (HBD). TM and HBD subjects revealed a homogeneous serological response to the Comirnaty (Mean ± SD; TM = 1917,21 ± 1384,49; HBD = 2039,81 ± 1064,44; p = 0,5884). No statistically significant differences were observed among two groups. Interestingly, we observed in 73.3% of asplenic patients Ab-S titres above 800 BAU, whereas only in 26% of non splenectomized patients showed Ab-S titres above 800 BAU). This differences were statistically significant p < 0.039. Further measurement on other Ab types was needed for better understanding humoral response to Comirnaty.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Beta-Thalassemia / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Microbes Infect Journal subject: Allergy and Immunology / Microbiology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Vaccines / Beta-Thalassemia / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: Microbes Infect Journal subject: Allergy and Immunology / Microbiology Year: 2022 Document Type: Article