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Humoral response to SARS-CoV-2 infection and vaccines against COVID-19 in patients with neuromyelitis optica spectrum disorders: Impact of immunosuppressive treatment.
Jovicevic, Vanja; Ivanovic, Jovana; Momcilovic, Nikola; Andabaka, Marko; Tamas, Olivera; Veselinovic, Nikola; Cujic, Danica; Gnjatovic, Marija; Mesaros, Sarlota; Pekmezovic, Tatjana; Drulovic, Jelena.
  • Jovicevic V; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia.
  • Ivanovic J; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia.
  • Momcilovic N; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia.
  • Andabaka M; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia.
  • Tamas O; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia.
  • Veselinovic N; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia.
  • Cujic D; Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, Belgrade 11080, Serbia.
  • Gnjatovic M; Institute for Application of Nuclear Energy, University of Belgrade, Banatska 31b, Belgrade 11080, Serbia.
  • Mesaros S; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia.
  • Pekmezovic T; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26A, Belgrade 11000, Serbia.
  • Drulovic J; Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, Belgrade 11000, Serbia; Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia. Electronic address: drulovicjelena@gmail.com.
Mult Scler Relat Disord ; 62: 103794, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1773654
ABSTRACT
The aim of this study was to evaluate the humoral response to the SARS-CoV-2 infection and vaccination in the NMOSD patients, treated with various immunosuppresants (ISs). Serum IgG against the complete sequence of the receptor binding domain of the spike protein was measured using ELISA SARS-CoV-2 IgG, INEP, Belgrade. Seroconversion occurred in 8/10 patients with COVID-19, and in 5/9 after vaccination. One out of four patients treated with inebilizumab seroconverted (after COVID-19); antibodies were not detected in any of the remaining 3 patients who were vaccinated. Antibodies developed after COVID-19 in 4/5 patients treated with azathioprine and all treated with mycophenolate-mofetil, and after vaccination, in 5/6 patients treated with these ISs. Post-vaccination humoral response was impaired in our NMOSD patients treated with B-cell depleting therapies; seroconversion occurred in almost all patients treated with conventional synthetic disease modifying ISs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neuromyelitis Optica / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article