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Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination.
Dhanasekaran, Vijaykrishna; Sullivan, Sheena; Edwards, Kimberly M; Xie, Ruopeng; Khvorov, Arseniy; Valkenburg, Sophie A; Cowling, Benjamin J; Barr, Ian G.
  • Dhanasekaran V; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. veej@hku.hk.
  • Sullivan S; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. veej@hku.hk.
  • Edwards KM; WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, 3000, Melbourne, VIC, Australia.
  • Xie R; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Khvorov A; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Valkenburg SA; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Cowling BJ; HKU-Pasteur Research Pole, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
  • Barr IG; WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, 3000, Melbourne, VIC, Australia.
Nat Commun ; 13(1): 1721, 2022 03 31.
Article in English | MEDLINE | ID: covidwho-1773976
ABSTRACT
Annual epidemics of seasonal influenza cause hundreds of thousands of deaths, high levels of morbidity, and substantial economic loss. Yet, global influenza circulation has been heavily suppressed by public health measures and travel restrictions since the onset of the COVID-19 pandemic. Notably, the influenza B/Yamagata lineage has not been conclusively detected since April 2020, and A(H3N2), A(H1N1), and B/Victoria viruses have since circulated with considerably less genetic diversity. Travel restrictions have largely confined regional outbreaks of A(H3N2) to South and Southeast Asia, B/Victoria to China, and A(H1N1) to West Africa. Seasonal influenza transmission lineages continue to perish globally, except in these select hotspots, which will likely seed future epidemics. Waning population immunity and sporadic case detection will further challenge influenza vaccine strain selection and epidemic control. We offer a perspective on the potential short- and long-term evolutionary dynamics of seasonal influenza and discuss potential consequences and mitigation strategies as global travel gradually returns to pre-pandemic levels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Influenza A Virus, H1N1 Subtype / COVID-19 Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-29402-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Influenza A Virus, H1N1 Subtype / COVID-19 Type of study: Observational study Topics: Vaccines Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-29402-5