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Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates.
Rutkai, Ibolya; Mayer, Meredith G; Hellmers, Linh M; Ning, Bo; Huang, Zhen; Monjure, Christopher J; Coyne, Carol; Silvestri, Rachel; Golden, Nadia; Hensley, Krystle; Chandler, Kristin; Lehmicke, Gabrielle; Bix, Gregory J; Maness, Nicholas J; Russell-Lodrigue, Kasi; Hu, Tony Y; Roy, Chad J; Blair, Robert V; Bohm, Rudolf; Doyle-Meyers, Lara A; Rappaport, Jay; Fischer, Tracy.
  • Rutkai I; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Mayer MG; Tulane National Primate Research Center, Covington, LA, USA.
  • Hellmers LM; Tulane National Primate Research Center, Covington, LA, USA.
  • Ning B; Department of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA, USA.
  • Huang Z; Department of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA, USA.
  • Monjure CJ; Tulane National Primate Research Center, Covington, LA, USA.
  • Coyne C; Tulane National Primate Research Center, Covington, LA, USA.
  • Silvestri R; Tulane National Primate Research Center, Covington, LA, USA.
  • Golden N; Tulane National Primate Research Center, Covington, LA, USA.
  • Hensley K; Tulane National Primate Research Center, Covington, LA, USA.
  • Chandler K; Tulane National Primate Research Center, Covington, LA, USA.
  • Lehmicke G; Tulane National Primate Research Center, Covington, LA, USA.
  • Bix GJ; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, USA.
  • Maness NJ; Tulane National Primate Research Center, Covington, LA, USA.
  • Russell-Lodrigue K; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Hu TY; Tulane National Primate Research Center, Covington, LA, USA.
  • Roy CJ; Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
  • Blair RV; Department of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine, New Orleans, LA, USA.
  • Bohm R; Tulane National Primate Research Center, Covington, LA, USA.
  • Doyle-Meyers LA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
  • Rappaport J; Tulane National Primate Research Center, Covington, LA, USA.
  • Fischer T; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Nat Commun ; 13(1): 1745, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1773978
ABSTRACT
Neurological manifestations are a significant complication of coronavirus disease (COVID-19), but underlying mechanisms aren't well understood. The development of animal models that recapitulate the neuropathological findings of autopsied brain tissue from patients who died from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are critical for elucidating the neuropathogenesis of infection and disease. Here, we show neuroinflammation, microhemorrhages, brain hypoxia, and neuropathology that is consistent with hypoxic-ischemic injury in SARS-CoV-2 infected non-human primates (NHPs), including evidence of neuron degeneration and apoptosis. Importantly, this is seen among infected animals that do not develop severe respiratory disease, which may provide insight into neurological symptoms associated with "long COVID". Sparse virus is detected in brain endothelial cells but does not associate with the severity of central nervous system (CNS) injury. We anticipate our findings will advance our current understanding of the neuropathogenesis of SARS-CoV-2 infection and demonstrate SARS-CoV-2 infected NHPs are a highly relevant animal model for investigating COVID-19 neuropathogenesis among human subjects.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-29440-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-29440-z